Protein: CDK6
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)

Gene: CDK6
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q00534

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001726 - ruffle
GO:0001954 - positive regulation of cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

673141

CCND3
G1/S-specific cyclin-D3

24

20

Small-scale

0.992

High

790967

CDN2C
Cyclin-dependent kinase 4 inhibitor C

20

17

Small-scale

0.991

High

790922

CDN2B
Cyclin-dependent kinase 4 inhibitor B

11

16

Small-scale

0.985

High

877470

CDN2D
Cyclin-dependent kinase 4 inhibitor D

12

17

Small-scale

0.984

High

622428

CCND1
G1/S-specific cyclin-D1

14

20

Small-scale

0.981

High

804105

CDN1B
Cyclin-dependent kinase inhibitor 1B

8

20

Small-scale

0.967

High

673062

CCND2
G1/S-specific cyclin-D2

7

20

Small-scale

0.962

High

758189

CDN1A
Cyclin-dependent kinase inhibitor 1

6

20

Small-scale

0.947

High

960185

CDC37
Hsp90 co-chaperone Cdc37

5

7

Small-scale

0.921

High

515399

CDK4
Cyclin-dependent kinase 4

3

16

High-throughput

0.866

High

236748

CCNT1
Cyclin-T1

3

20

High-throughput

0.861

High

237390

CCNT2
Cyclin-T2

3

20

High-throughput

0.861

High

836899

CDN1C
Cyclin-dependent kinase inhibitor 1C

3

20

High-throughput

0.861

High

960237

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

3

19

High-throughput

0.861

High

330979

PAK4
Serine/threonine-protein kinase PAK 4

2

11

High-throughput

0.811

High

960166

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

13

High-throughput

0.811

High

438076

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.802

High

851198

CCNH
Cyclin-H

2

20

High-throughput

0.783

High

960168

CCNI
Cyclin-I

2

20

High-throughput

0.783

High

624574

CCNE1
G1/S-specific cyclin-E1

2

20

Small-scale

0.768

High

960147

CDK6
Cyclin-dependent kinase 6

2

16

High-throughput

0.768

High

790748

CDN2A
Cyclin-dependent kinase inhibitor 2A

19

15

Small-scale

0.767

High

414245

RB
Retinoblastoma-associated protein

10

20

Small-scale

0.755

High

659653

MZF1
Myeloid zinc finger 1

1

1

Small-scale

0.735

High

925004

TRA2B
Transformer-2 protein homolog beta

1

6

Small-scale

0.735

High

960151

SRSF2
Serine/arginine-rich splicing factor 2

1

3

Small-scale

0.735

High

960156

SRS11
Serine/arginine-rich splicing factor 11

1

3

Small-scale

0.735

High

960157

SRSF1
Serine/arginine-rich splicing factor 1

1

6

Small-scale

0.735

High

960161

KLF10
Krueppel-like factor 10

1

4

Small-scale

0.735

High

960167

TRA2A
Transformer-2 protein homolog alpha

1

9

Small-scale

0.735

High

960181

ZN174
Zinc finger protein 174

1

2

Small-scale

0.735

High

960186

SRSF7
Serine/arginine-rich splicing factor 7

1

7

Small-scale

0.735

High

960198

ANR12
Ankyrin repeat domain-containing protein 12

1

7

Small-scale

0.735

High

960206

RBM23
Probable RNA-binding protein 23

1

8

Small-scale

0.735

High

960210

ZN101
Zinc finger protein 101

1

4

Small-scale

0.735

High

960215

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

3

Small-scale

0.735

High

960219

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.735

High

960220

SRS12
Serine/arginine-rich splicing factor 12

1

5

Small-scale

0.735

High

960221

DEDD2
DNA-binding death effector domain-containing protein 2

1

1

Small-scale

0.735

High

960247

BC11A
B-cell lymphoma/leukemia 11A

1

3

Small-scale

0.735

High

960249

ZN335
Zinc finger protein 335

1

1

Small-scale

0.735

High

960261

TPX2
Targeting protein for Xklp2

1

2

Small-scale

0.735

High

299256

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

4

Small-scale

0.724

High

960232

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

3

Small-scale

0.724

High

960191

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

273419

PPM1B
Protein phosphatase 1B

1

7

Small-scale

0.710

High

741026

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.697

High

960256

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.697

High

960148

CDK5
Cyclin-dependent kinase 5

1

17

High-throughput

0.691

High

960208

CDKL3
Cyclin-dependent kinase-like 3

1

18

High-throughput

0.691

High

960230

PPM1M
Protein phosphatase 1M

1

10

High-throughput

0.691

High

960227

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

2

High-throughput

0.667

High

374058

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

19

High-throughput

0.647

High

383745

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.647

High

441483

MET
Hepatocyte growth factor receptor

1

11

High-throughput

0.647

High

488680

ARAF
Serine/threonine-protein kinase A-Raf

1

19

High-throughput

0.647

High

557094

PGFRA
Platelet-derived growth factor receptor alpha

1

14

High-throughput

0.647

High

560120

ZN823
Zinc finger protein 823

1

2

Small-scale

0.647

High

607942

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.647

High

665211

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.647

High

681793

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.647

High

805394

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.647

High

841165

CDK7
Cyclin-dependent kinase 7

1

17

Small-scale

0.647

High

960163

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.647

High

960182

STK11
Serine/threonine-protein kinase STK11

1

12

High-throughput

0.647

High

960184

MK14
Mitogen-activated protein kinase 14

1

19

High-throughput

0.647

High

960216

GLIS1
Zinc finger protein GLIS1

1

8

High-throughput

0.647

High

960234

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

17

High-throughput

0.647

High

960243

GLIS2
Zinc finger protein GLIS2

1

8

High-throughput

0.647

High

960253

LATS2
Serine/threonine-protein kinase LATS2

1

12

High-throughput

0.647

High

960254

RASF1
Ras association domain-containing protein 1

1

8

High-throughput

0.647

High

346535

MYC
Myc proto-oncogene protein

2

6

Small-scale

0.633

High

960207

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

4

High-throughput

0.628

High

232848

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

6

High-throughput

0.618

High

384654

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

431742

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

575374

EGR1
Early growth response protein 1

1

2

High-throughput

0.618

High

590163

CCNA2
Cyclin-A2

1

20

Small-scale

0.618

High

960150

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

8

Small-scale

0.618

High

960155

FAK1
Focal adhesion kinase 1

1

16

Small-scale

0.618

High

960178

CD5R1
Cyclin-dependent kinase 5 activator 1

1

8

Small-scale

0.618

High

960190

LARP7
La-related protein 7

1

10

High-throughput

0.618

High

960199

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

960233

Q96TE0
Cyclin-dependent kinase inhibitor 1B

1

20

Small-scale

0.618

High

782740

ABEC1
C->U-editing enzyme APOBEC-1

2

1

High-throughput

0.606

High

960194

OTP
Homeobox protein orthopedia

2

8

High-throughput

0.606

High

960244

TRI15
E3 ubiquitin-protein ligase TRIM15

2

3

High-throughput

0.606

High

960154

H11
Histone H1.1

2

20

Small-scale

0.602

High

960225

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.589

High

269136

DAB1
Disabled homolog 1

2

6

Small-scale

0.586

High

960231

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

High-throughput

0.585

High

353402

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.578

High

960197

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

9

Small-scale

0.578

High

960200

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

6

Small-scale

0.578

High

625364

CDK2
Cyclin-dependent kinase 2

1

14

Small-scale

0.575

High

960192

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

19

High-throughput

0.575

High

172846

CASC3
Protein CASC3

1

1

Small-scale

0.569

High

206826

FOXO3
Forkhead box protein O3

1

12

Small-scale

0.569

High

660117

RBL1
Retinoblastoma-like protein 1

1

20

Small-scale

0.569

High

668601

PML
Protein PML

1

9

Small-scale

0.569

High

727728

SOX5
Transcription factor SOX-5

1

9

Small-scale

0.569

High

788025

AF9
Protein AF-9

1

5

Small-scale

0.569

High

881796

SOX10
Transcription factor SOX-10

1

9

Small-scale

0.569

High

899919

ISL1
Insulin gene enhancer protein ISL-1

1

4

Small-scale

0.569

High

946638

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.569

High

960149

HSF1
Heat shock factor protein 1

1

8

Small-scale

0.569

High

960158

FOXM1
Forkhead box protein M1

1

7

Small-scale

0.569

High

960159

RBL2
Retinoblastoma-like protein 2

1

20

Small-scale

0.569

High

960160

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

9

Small-scale

0.569

High

960171

TFDP1
Transcription factor Dp-1

1

9

Small-scale

0.569

High

960174

SLBP
Histone RNA hairpin-binding protein

1

3

Small-scale

0.569

High

960175

LPIN1
Phosphatidate phosphatase LPIN1

1

1

Small-scale

0.569

High

960176

MEF2D
Myocyte-specific enhancer factor 2D

1

7

Small-scale

0.569

High

960177

NUMA1
Nuclear mitotic apparatus protein 1

1

15

Small-scale

0.569

High

960183

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

Small-scale

0.569

High

960195

NIPBL
Nipped-B-like protein

1

5

Small-scale

0.569

High

960209

ELOA2
Elongin-A2

1

3

Small-scale

0.569

High

960212

CLASR
CLK4-associating serine/arginine rich protein

1

2

Small-scale

0.569

High

960228

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.569

High

960235

CDC6
Cell division control protein 6 homolog

1

12

Small-scale

0.569

High

960236

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

Small-scale

0.569

High

960239

SRBS1
Sorbin and SH3 domain-containing protein 1

1

2

Small-scale

0.569

High

960240

PRAX
Periaxin

1

7

Small-scale

0.569

High

960248

SENP3
Sentrin-specific protease 3

1

3

Small-scale

0.569

High

960257

ZO2
Tight junction protein ZO-2

1

3

Small-scale

0.569

High

960263

SYNP2
Synaptopodin-2

1

1

Small-scale

0.569

High

960264

TRAK1
Trafficking kinesin-binding protein 1

1

14

Small-scale

0.569

High

930806

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.550

High

254396

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.545

High

584235

ELK1
ETS domain-containing protein Elk-1

1

0

Small-scale

0.545

High

727130

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.545

High

960169

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

Small-scale

0.545

High

960172

ZMYM3
Zinc finger MYM-type protein 3

1

0

Small-scale

0.545

High

960204

POGZ
Pogo transposable element with ZNF domain

1

0

Small-scale

0.545

High

960214

MS3L1
MSL complex subunit 3

1

0

Small-scale

0.545

High

960217

PPHLN
Periphilin-1

1

0

Small-scale

0.545

High

960238

COE4
Transcription factor COE4

1

0

Small-scale

0.545

High

960252

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

Small-scale

0.545

High

960266

CBY1
Protein chibby homolog 1

1

0

Small-scale

0.545

High

868430

ATX1
Ataxin-1

1

3

High-throughput

0.541

High

832374

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.536

High

336469

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

517198

PCNA
Proliferating cell nuclear antigen

1

9

High-throughput

0.536

High

929283

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.536

High

960193

BSPRY
B box and SPRY domain-containing protein

1

4

High-throughput

0.536

High

960196

KLC3
Kinesin light chain 3

1

5

High-throughput

0.536

High

960226

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

960245

WDR33
pre-mRNA 3' end processing protein WDR33

1

6

High-throughput

0.536

High

960250

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.536

High

960251

E41L5
Band 4.1-like protein 5

1

8

High-throughput

0.536

High

960259

DMBT1
Deleted in malignant brain tumors 1 protein

1

1

High-throughput

0.536

High

456547

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

Small-scale

0.515

High

960152

RUNX1
Runt-related transcription factor 1

1

3

Small-scale

0.515

High

960202

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.513

High

960205

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.513

High

960267

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

154019

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

386532

P53
Cellular tumor antigen p53

1

7

High-throughput

0.501

High

555125

CD44
CD44 antigen

1

1

High-throughput

0.501

High

644239

TTP
mRNA decay activator protein ZFP36

1

4

Small-scale

0.501

High

649086

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

8

High-throughput

0.501

High

719449

MERL
Merlin

1

8

High-throughput

0.501

High

928061

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.501

High

960164

GRM1
Metabotropic glutamate receptor 1

1

3

High-throughput

0.501

High

960173

BECN1
Beclin-1

1

1

High-throughput

0.501

High

960180

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

960187

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

High-throughput

0.501

High

960188

KI26B
Kinesin-like protein KIF26B

1

6

Small-scale

0.501

High

960211

ABI1
Abl interactor 1

1

4

Small-scale

0.501

High

960223

TSC1
Hamartin

1

17

High-throughput

0.501

High

960224

KAT2A
Histone acetyltransferase KAT2A

1

9

High-throughput

0.501

High

960255

ABI2
Abl interactor 2

1

3

Small-scale

0.501

High

960262

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.501

High

637853

PSA3
Proteasome subunit alpha type-3

1

6

High-throughput

0.481

High

960170

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.480

High

960260

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.480

High

233372

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

303168

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

521866

CADH1
Cadherin-1

1

3

Small-scale

0.479

High

552507

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

716997

CTNB1
Catenin beta-1

1

10

Small-scale

0.479

High

742219

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

896416

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

Small-scale

0.479

High

908382

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

930142

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.479

High

960153

RELB
Transcription factor RelB

1

8

Small-scale

0.479

High

960162

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

9

High-throughput

0.479

High

960165

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

960179

IRF4
Interferon regulatory factor 4

1

2

Small-scale

0.479

High

960189

EMAL3
Echinoderm microtubule-associated protein-like 3

1

4

High-throughput

0.479

High

960201

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

960203

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

960218

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.479

High

960222

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

960229

EGLN2
Prolyl hydroxylase EGLN2

1

6

Small-scale

0.479

High

960246

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

960258

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

960241

RTF2
Replication termination factor 2

1

0

High-throughput

0.458

High

960265

FBX7
F-box only protein 7

1

0

Small-scale

0.458

High

536132

HGF
Hepatocyte growth factor

1

1

High-throughput

0.457

High

584379

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.457

High

708213

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.457

High

960242

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

960213

CAHM5
Calcium homeostasis modulator protein 5

2

0

High-throughput

0.319

High

245487

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

388024

AMYP
Pancreatic alpha-amylase

1

0

High-throughput

0.279

Low

611557

CAH4
Carbonic anhydrase 4

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024