HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: 2A5G (Q13362)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)
Gene: PPP2R5C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	27173435, 21460856, 33961781, 15380617, 26496610, 28330616, 18782753, 19156129, 23443559, 8617797, 19915589, 17245430
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	B56~HEAT_2
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0000775 - chromosome, centromeric region GO:0005634 - nucleus GO:0005829 - cytosol GO:0019888 - protein phosphatase regulator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 589 Hs			1 524
+	Hs
		672415 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5G_HUMAN (1-524): 0: 898: 100.00
+	Hs
		672187 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		Q7L7W2_HUMAN (11-524): 0: 872: 99.81
+	Hs
		672123 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5D_HUMAN (23-523): 0: 821: 80.52
+	Hs
		672422 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5D_HUMAN (23-523): 0: 821: 80.52
+	Dm
		734216 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		Q9VEC6_DROME (25-488): 0: 764: 70.08
+	Hs
		672140 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5E_HUMAN (21-436): 0: 673: 72.12
+	Hs
		672129 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5A_HUMAN (23-417): 0: 667: 72.15
+	Hs
		672130 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5B_HUMAN (18-436): 0: 662: 68.50
+	Hs
		672428 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5E_HUMAN (21-436): 0: 673: 72.12
+	Dm
		47131 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		A0A6F7R657_DROME (22-438): 0: 697: 72.01
+	Hs
		672425 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5A_HUMAN (23-417): 0: 667: 72.15
+	Hs
		672426 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5B_HUMAN (18-436): 0: 662: 68.50
+	Dm
		734212 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		Q9VB23_DROME (22-438): 0: 690: 72.01
+	Ce
		999428 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		Q17948_CAEEL (23-518): 0: 760: 63.73
+	Ce
		999433 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		Q9U3Q1_CAEEL (23-518): 0: 760: 63.73
+	Ce
		110946 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		H9G2X3_CAEEL (23-518): 0: 758: 63.73
+	At
		1104795 2AAA_ARATH (92-587): 3.85e-48: 178: 17.74		2A5G_ARATH (17-460): 0: 714: 50.90
+	At
		1105298 2AAB_ARATH (92-587): 9.45e-46: 172: 18.15		2A5N_ARATH (20-437): 0: 719: 55.11
+	At
		1105306 2AAG_ARATH (92-587): 7.34e-45: 169: 17.74		2A5N_ARATH (20-437): 0: 719: 55.11
+	At
		138268 2AAA_ARATH (92-587): 3.85e-48: 178: 17.74		2A5B_ARATH (26-439): 0: 692: 52.16