HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	14676191
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT~Pkinase, HEAT_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0015630 - microtubule cytoskeleton GO:0030425 - dendrite GO:0035556 - intracellular signal transduction and 1 others more... GO:0043005 - neuron projection
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 589 Hs			1 752
+	Hs
		647833 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Hs
		672185 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		672056 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	Hs
		672294 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		SIK2_HUMAN (56-367): 5.39e-104: 341: 55.17
+	Hs
		672472 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		SIK2_HUMAN (56-367): 5.39e-104: 341: 55.17
+	At
		1103381 2AAA_ARATH (92-587): 3.85e-48: 178: 17.74		CIPK3_ARATH (46-455): 1.79e-150: 447: 29.47
+	Hs
		1273247 TNPO1_HUMAN (24-483): 2.91e-20: 97.2: 15.05		SIK3_HUMAN (56-367): 1.81e-109: 363: 59.32