HitPredict

Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	19826003, 17827148, 22942284
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 824 Hs			1 2089
+	Hs
		672821 CDC27_HUMAN (1-824): 0: 625: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1057017 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		672854 CDC27_HUMAN (1-824): 0: 625: 100.00		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1057016 CDC23_HUMAN (371-823): 1.24e-24: 111: 12.64		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		174891 OGT1_HUMAN (77-583): 5.18e-24: 110: 9.25		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1022899 CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1019165 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1173268 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1019164 CDC23_HUMAN (371-823): 1.24e-24: 111: 12.64		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		174836 OGT1_HUMAN (77-583): 5.18e-24: 110: 9.25		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		801454 CDC23_HUMAN (371-823): 1.24e-24: 111: 12.64		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		174698 OGT1_HUMAN (77-583): 5.18e-24: 110: 9.25		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		1018938 CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1173267 CDC23_HUMAN (371-823): 1.24e-24: 111: 12.64		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1022924 CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56