Protein: ELO3
Fatty acid elongase 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELO3) (Affecting plasma membrane ATPase activity protein 1) (Elongation of fatty acids protein 3) (Suppressor of RAD3 essential function protein 1) (Suppressor of Rvs161 and Rvs167 mutations protein 4) (Very-long-chain 3-oxoacyl-CoA synthase 3) (v-SNARE bypass mutant gene 1 protein)

Gene: ELO3
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: P40319

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006633 - fatty acid biosynthetic process
GO:0006892 - post-Golgi vesicle-mediated transport
GO:0009922 - fatty acid elongase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

812873

ELO1
Fatty acid elongase 1

1

4

High-throughput

0.698

High

822362

TECR
Very-long-chain enoyl-CoA reductase

3

5

Small-scale

0.658

High

554352

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

2

1

High-throughput

0.614

High

703821

LAC1
Ceramide synthase LAC1

2

8

High-throughput

0.614

High

745346

EMP24
Endosomal protein P24B

2

4

High-throughput

0.614

High

748420

SC61A
Protein transport protein SEC61

2

3

High-throughput

0.614

High

754627

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

798646

SSH1
Sec sixty-one protein homolog

2

3

High-throughput

0.614

High

805790

NSG1
Protein NSG1

2

1

High-throughput

0.614

High

822324

ERV14
ER-derived vesicles protein ERV14

2

1

High-throughput

0.614

High

822330

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

2

1

High-throughput

0.614

High

524123

HSP71
Heat shock protein SSA1

4

5

High-throughput

0.608

High

822308

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

2

4

High-throughput

0.608

High

822339

GSF2
Glucose-signaling factor 2

2

0

High-throughput

0.588

High

796949

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.584

High

416707

CAN1
Arginine permease CAN1

1

20

High-throughput

0.541

High

448258

HIP1
Histidine permease

1

19

High-throughput

0.541

High

583759

SEC11
Signal peptidase complex catalytic subunit SEC11

1

1

High-throughput

0.541

High

592771

ERD1
Protein ERD1

1

1

High-throughput

0.541

High

598512

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

1

High-throughput

0.541

High

645109

EPT1
Choline/ethanolaminephosphotransferase 1

1

1

High-throughput

0.541

High

671368

PHO84
Inorganic phosphate transporter PHO84

1

6

High-throughput

0.541

High

673426

AGP1
General amino acid permease AGP1

1

19

High-throughput

0.541

High

735840

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.541

High

751826

SGE1
Protein SGE1

1

9

High-throughput

0.541

High

763798

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

2

High-throughput

0.541

High

793269

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

19

High-throughput

0.541

High

797597

YPC1
Alkaline ceramidase YPC1

1

1

High-throughput

0.541

High

798713

BSD2
Metal homeostatis protein BSD2

1

2

High-throughput

0.541

High

803025

YHE2
Putative uncharacterized protein YHL042W

1

9

High-throughput

0.541

High

805328

ERP5
Protein ERP5

1

4

High-throughput

0.541

High

805885

YHU0
UPF0641 membrane protein YHR140W

1

2

High-throughput

0.541

High

805923

CHS7
Chitin synthase export chaperone

1

2

High-throughput

0.541

High

808680

SUR2
Sphingolipid C4-hydroxylase SUR2

1

6

High-throughput

0.541

High

808708

FET3
Iron transport multicopper oxidase FET3

1

2

High-throughput

0.541

High

822299

MMM1
Maintenance of mitochondrial morphology protein 1

1

1

High-throughput

0.541

High

822300

BAP3
Valine amino-acid permease

1

19

High-throughput

0.541

High

822303

EMP47
Protein EMP47

1

1

High-throughput

0.541

High

822307

PHO86
Inorganic phosphate transporter PHO86

1

1

High-throughput

0.541

High

822309

SPC1
Signal peptidase complex subunit 1

1

3

High-throughput

0.541

High

822316

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.541

High

822321

ERG25
C-4 methylsterol oxidase ERG25

1

6

High-throughput

0.541

High

822325

TNA1
High-affinity nicotinic acid transporter

1

11

High-throughput

0.541

High

822328

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

2

High-throughput

0.541

High

822334

NHX1
Endosomal/prevacuolar sodium/hydrogen exchanger

1

1

High-throughput

0.541

High

822349

PMT7
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

1

5

High-throughput

0.541

High

822353

THI73
Thiamine pathway transporter THI73

1

10

High-throughput

0.541

High

822357

YP264
Probable transport protein YPL264C

1

1

High-throughput

0.541

High

822358

POM33
Pore membrane protein of 33 kDa

1

2

High-throughput

0.541

High

822360

MMP1
S-methylmethionine permease 1

1

18

High-throughput

0.541

High

822304

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

526838

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.521

High

545082

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.521

High

817868

IMB4
Importin subunit beta-4

2

3

High-throughput

0.521

High

780357

MCD4
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.518

High

793130

YRO2
Protein YRO2

1

0

High-throughput

0.518

High

806413

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.518

High

818104

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.518

High

822312

YJY5
Uncharacterized endoplasmic reticulum membrane protein YJR015W

1

0

High-throughput

0.518

High

822347

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.518

High

822364

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4

1

0

High-throughput

0.518

High

818901

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.504

High

678064

FEN2
Pantothenate transporter FEN2

1

10

High-throughput

0.494

High

737228

HXT1
Low-affinity glucose transporter HXT1

1

5

High-throughput

0.494

High

747190

PMP1
Plasma membrane ATPase proteolipid 1

1

2

High-throughput

0.494

High

794376

MAL31
Maltose permease MAL31

1

10

High-throughput

0.494

High

802993

COS8
Protein COS8

1

10

High-throughput

0.494

High

822295

HXT8
Hexose transporter HXT8

1

5

High-throughput

0.494

High

822296

VTH2
VPS10 homolog 2

1

1

High-throughput

0.494

High

822298

PMP2
Plasma membrane ATPase proteolipid 2

1

2

High-throughput

0.494

High

822302

COS4
Protein COS4

1

10

High-throughput

0.494

High

822320

AVT4
Vacuolar amino acid transporter 4

1

5

High-throughput

0.494

High

822322

MAL11
General alpha-glucoside permease

1

10

High-throughput

0.494

High

822323

VPS73
Vacuolar protein sorting-associated protein 73

1

6

High-throughput

0.494

High

822326

COS6
Protein COS6

1

10

High-throughput

0.494

High

822329

HXT11
Hexose transporter HXT11

1

5

High-throughput

0.494

High

822333

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

5

High-throughput

0.494

High

822345

TPO3
Polyamine transporter 3

1

9

High-throughput

0.494

High

822350

MCH1
Probable transporter MCH1

1

1

High-throughput

0.494

High

822352

TPO1
Polyamine transporter 1

1

9

High-throughput

0.494

High

822354

GAS4
1,3-beta-glucanosyltransferase GAS4

1

5

High-throughput

0.494

High

822361

POM34
Nucleoporin POM34

1

1

High-throughput

0.494

High

554431

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

577147

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

636317

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

668455

SPTC1
Serine palmitoyltransferase 1

1

1

High-throughput

0.479

High

672158

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

High-throughput

0.479

High

715037

ERG9
Squalene synthase ERG9

1

1

High-throughput

0.479

High

726093

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

735340

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

6

High-throughput

0.479

High

748608

SRPR
Signal recognition particle receptor subunit alpha homolog

1

1

High-throughput

0.479

High

751701

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

3

High-throughput

0.479

High

754695

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

776366

YET1
Endoplasmic reticulum transmembrane protein 1

1

4

High-throughput

0.479

High

797396

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

5

High-throughput

0.479

High

802484

LAG1
Ceramide synthase LAG1

1

8

High-throughput

0.479

High

809017

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

1

High-throughput

0.479

High

816192

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

4

High-throughput

0.479

High

822294

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.479

High

822297

LCB2
Serine palmitoyltransferase 2

1

1

High-throughput

0.479

High

822305

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

2

High-throughput

0.479

High

822310

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

822314

STE24
CAAX prenyl protease 1

1

1

High-throughput

0.479

High

822315

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

822338

HFD1
Fatty aldehyde dehydrogenase HFD1

1

5

High-throughput

0.479

High

822341

RTN1
Reticulon-like protein 1

1

2

High-throughput

0.479

High

822351

YET3
Endoplasmic reticulum transmembrane protein 3

1

4

High-throughput

0.479

High

822356

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

1

High-throughput

0.479

High

428007

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.458

High

677107

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

678009

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

735312

ERG2
C-8 sterol isomerase ERG2

1

0

High-throughput

0.458

High

754401

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

782213

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.458

High

802000

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.458

High

803569

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

806436

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

822313

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

822327

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

822336

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

822342

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

822343

YP114
Uncharacterized TLC domain-containing protein YPR114W

1

0

High-throughput

0.458

High

822346

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.458

High

822363

SEY1
Protein SEY1

1

0

High-throughput

0.458

High

822365

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

506219

MPH3
Alpha-glucosides permease MPH3

1

10

High-throughput

0.439

High

822293

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

727075

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

734682

IMB3
Importin subunit beta-3

1

4

High-throughput

0.437

High

758452

YKK0
Probable intramembrane protease YKL100C

1

2

High-throughput

0.437

High

796084

IMB2
Importin subunit beta-2

1

3

High-throughput

0.437

High

822317

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.437

High

822332

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

822344

IMB1
Importin subunit beta-1

1

3

High-throughput

0.437

High

359249

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.407

High

416128

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

417111

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.407

High

432603

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.407

High

444539

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.407

High

531765

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.407

High

592284

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

741687

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

802631

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.407

High

822318

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.407

High

822359

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.407

High

394613

EF1A
Elongation factor 1-alpha

2

0

High-throughput

0.298

High

560282

KEX2
Kexin

1

0

High-throughput

0.282

High

663606

VATO
V-type proton ATPase subunit c''

1

0

High-throughput

0.282

High

751086

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.282

High

822348

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.282

High

656791

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.261

Low

647127

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

677424

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

721991

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

755107

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.249

Low

781512

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.249

Low

806733

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

812355

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

822301

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

822306

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.249

Low

822311

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

822331

PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.249

Low

822335

SXM1
Importin beta SMX1

1

0

High-throughput

0.249

Low

822337

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

822340

TVP18
Golgi apparatus membrane protein TVP18

1

0

High-throughput

0.249

Low

822355

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

358237

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

383731

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.232

Low

386730

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

427306

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

433221

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.232

Low

438444

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.232

Low

486200

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

670278

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.232

Low

753403

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.232

Low

801056

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

822319

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025