HitPredict

Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	11691834, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 824 Hs			1 467
+	Hs
		672809 CDC27_HUMAN (1-824): 0: 625: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		174919 OGT1_HUMAN (77-583): 5.18e-24: 110: 9.25		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1022903 CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		950162 CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1035626 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		171409 SKI3_HUMAN (14-783): 5.8e-11: 68.8: 12.38		SMAD9_HUMAN (1-467): 0: 564: 54.56