HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.914

The method score is based on:

Property Details
Experiments 25659891, 32707033, 18469858, 15070733
Identification Methods affinity chromatography technology, pull down, enzymatic study, kinase homogeneous time resolved fluorescence
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000287 - magnesium ion binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 1 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 646
Hs

1 603
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024