HitPredict

Interactor 1: MPIP1 (P30304)
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
Gene: CDC25A

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27432908
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Rhodanese
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008283 - cell population proliferation GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 524 Hs			1 305
+	Hs
		625158 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		414767 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		673389 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Rn
		823140 MPIP1_RAT (1-524): 0: 673: 84.09		CDK5_RAT (1-292): 3.8e-132: 378: 60.75
+	Hs
		673468 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		625159 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Rn
		823142 MPIP2_RAT (30-522): 0: 564: 41.51		CDK5_RAT (1-292): 3.8e-132: 378: 60.75
+	Hs
		414768 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		673469 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		625160 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		673470 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK16_HUMAN (1-288): 4.21e-108: 324: 54.33
+	Hs
		414769 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		673567 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Rn
		89020 D4ADT2_RAT (31-523): 1.86e-140: 414: 30.42		CDK5_RAT (1-292): 3.8e-132: 378: 60.75
+	Mm
		509473 MPIP3_MOUSE (1-523): 2.66e-127: 380: 29.02		CDK1_MOUSE (1-290): 1.15e-136: 390: 66.32
+	Dm
		618386 TWINE_DROME (213-508): 6.99e-89: 281: 33.22		CDK1_DROME (1-288): 2.07e-133: 381: 65.40
+	Sp
		383444 MPIP_SCHPO (195-509): 1.08e-89: 288: 26.65		CDK1_SCHPO (1-288): 1.98e-129: 371: 63.05
+	Sc
		339449 MPIP_YEAST (357-509): 7.06e-55: 195: 35.37		CDK1_YEAST (3-288): 1.32e-131: 377: 63.92