HitPredict

Interactor 1: HLAF (P30511)
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)
Gene: HLA-F

Interactor 2: KI2S4 (P43632)
Killer cell immunoglobulin-like receptor 2DS4 (CD158 antigen-like family member I) (Natural killer-associated transcript 8) (NKAT-8) (P58 natural killer cell receptor clones CL-39/CL-17) (p58 NK receptor CL-39/CL-17) (CD antigen CD158i)
Gene: KIR2DS4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	24018270, 27649529
Identification Methods	surface plasmon resonance, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1-set~ig, MHC_I~ig
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 304
+	Hs
		798280 Q5S3G3_HUMAN (1-345): 1.47e-169: 478: 80.58		KI2S4_HUMAN (1-304): 2.69e-114: 333: 100.00
+	Hs
		798195 Q5S3G3_HUMAN (1-345): 1.47e-169: 478: 80.58		KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16
+	Hs
		798194 Q5RIP0_HUMAN (1-345): 2.27e-160: 454: 77.17		KI2L3_HUMAN (1-304): 4.35e-106: 314: 88.16
+	Hs
		798173 Q5RIP0_HUMAN (1-345): 2.27e-160: 454: 77.17		KI2L2_HUMAN (1-303): 6.82e-104: 309: 88.12
+	Hs
		798148 Q5RIP0_HUMAN (1-345): 2.27e-160: 454: 77.17		KI2L1_HUMAN (1-303): 1.4e-103: 308: 87.46
+	Hs
		798171 Q5D1W8_HUMAN (1-345): 7.6e-159: 451: 77.46		KI2L2_HUMAN (1-303): 6.82e-104: 309: 88.12
+	Hs
		798146 Q5D1W8_HUMAN (1-345): 7.6e-159: 451: 77.46		KI2L1_HUMAN (1-303): 1.4e-103: 308: 87.46
+	Hs
		382484 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		LIRB4_HUMAN (1-304): 1.07e-68: 221: 29.51
+	Hs
		1060406 Q95J06_HUMAN (1-345): 6.76e-175: 491: 80.87		KI3S1_HUMAN (1-246): 2.84e-56: 188: 35.74
+	Hs
		47499 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		A0A8I5QEB2_HUMAN (1-246): 1.17e-58: 194: 40.16
+	Hs
		382420 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		KI3S1_HUMAN (1-246): 2.84e-56: 188: 35.74
+	Hs
		382341 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		KI3L2_HUMAN (1-246): 1.43e-54: 185: 38.96
+	Hs
		798244 Q5S3G3_HUMAN (1-345): 1.47e-169: 478: 80.58		KI3L2_HUMAN (1-246): 1.43e-54: 185: 38.96
+	Hs
		1060403 Q5SUL5_HUMAN (1-345): 2.11e-167: 472: 79.71		KI3S1_HUMAN (1-246): 2.84e-56: 188: 35.74
+	Hs
		1245576 Q95J06_HUMAN (1-345): 6.76e-175: 491: 80.87		LIRB1_HUMAN (21-258): 8.15e-40: 149: 35.39
+	Hs
		382485 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		LIRB1_HUMAN (21-258): 8.15e-40: 149: 35.39
+	Hs
		1130838 Q5S3G3_HUMAN (1-345): 1.47e-169: 478: 80.58		LIRB1_HUMAN (21-258): 8.15e-40: 149: 35.39
+	Hs
		1232786 Q95J06_HUMAN (1-345): 6.76e-175: 491: 80.87		LIRB2_HUMAN (10-138): 5.67e-15: 77.1: 35.66
+	Hs
		382478 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		LIRB2_HUMAN (10-138): 5.67e-15: 77.1: 35.66
+	Hs
		1130837 Q5S3G3_HUMAN (1-345): 1.47e-169: 478: 80.58		LIRB2_HUMAN (10-138): 5.67e-15: 77.1: 35.66