HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~fn3
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 986
+	Hs
		1018341 MERTK_HUMAN (7-861): 0: 588: 40.53		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Hs
		855777 EPHA4_HUMAN (2-836): 0: 637: 19.40		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Hs
		445865 ROS1_HUMAN (284-804): 1.68e-56: 214: 31.27		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Mm
		110600 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		H3BJU7_MOUSE (28-986): 0: 698: 88.63
+	Mm
		1112683 EPHB1_MOUSE (2-833): 0: 621: 20.81		Q3UHH6_MOUSE (14-814): 1e-86: 307: 15.94
+	Rn
		70090 B2B9B0_RAT (2-837): 0: 595: 19.75		D3ZWV8_RAT (17-814): 8.65e-94: 328: 16.93
+	Mm
		975163 EPHA2_MOUSE (3-837): 0: 583: 19.28		Q3UHH6_MOUSE (14-814): 1e-86: 307: 15.94
+	Hs
		665261 EPHA2_HUMAN (3-837): 0: 604: 19.66		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06
+	Hs
		548695 MERTK_HUMAN (7-861): 0: 588: 40.53		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		279867 EPHA7_HUMAN (2-837): 0: 621: 19.50		TRIO_HUMAN (224-927): 2.52e-66: 246: 12.28
+	Hs
		665608 EPHB2_HUMAN (2-837): 0: 605: 19.58		ITSN1_HUMAN (222-600): 5.07e-70: 257: 22.28
+	Hs
		411523 INSR_HUMAN (272-851): 1.65e-136: 443: 27.97		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Hs
		411288 INSR_HUMAN (272-851): 1.65e-136: 443: 27.97		VAV_HUMAN (142-680): 1.01e-84: 293: 15.54
+	Hs
		441472 MET_HUMAN (536-799): 3.42e-66: 243: 45.90		VAV2_HUMAN (40-788): 3.5e-103: 344: 13.46
+	Hs
		441580 MET_HUMAN (536-799): 3.42e-66: 243: 45.90		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Hs
		445884 ROS1_HUMAN (284-804): 1.68e-56: 214: 31.27		VAV3_HUMAN (40-828): 1.15e-98: 331: 12.49
+	Mm
		57826 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		KALRN_MOUSE (224-886): 3.77e-76: 276: 12.32
+	Mm
		554983 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		TRIO_MOUSE (224-927): 1.48e-66: 247: 12.08
+	Mm
		100126 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		F6U8U1_MOUSE (235-400): 1.5e-50: 183: 25.90
+	Hs
		601605 FGFR2_HUMAN (27-239): 5.42e-33: 139: 14.46		ITSN2_HUMAN (222-599): 8.01e-67: 247: 22.90