Protein: RSC8
Chromatin structure-remodeling complex protein RSC8 (Remodel the structure of chromatin complex subunit 8) (SWI3 homolog)

Gene: RSC8
Organism: Saccharomyces cerevisiae S288C
Interactions: 185
UniProt ID: P43609

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006303 - double-strand break repair via nonhomologous end joining
GO:0006337 - nucleosome disassembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850581

SFH1
Chromatin structure-remodeling complex subunit SFH1

8

9

Small-scale

0.967

High

850538

RSC8
Chromatin structure-remodeling complex protein RSC8

3

15

Small-scale

0.845

High

850562

GCN5
Histone acetyltransferase GCN5

2

20

High-throughput

0.776

High

743105

STH1
Nuclear protein STH1/NPS1

13

20

Small-scale

0.761

High

850584

RSC2
Chromatin structure-remodeling complex subunit RSC2

14

20

Small-scale

0.759

High

678329

RSC6
Chromatin structure-remodeling complex protein RSC6

10

18

Small-scale

0.758

High

745595

RSC7
Chromatin structure-remodeling complex subunit RSC7

7

1

Small-scale

0.749

High

850604

ARP7
Actin-related protein 7

7

16

Small-scale

0.746

High

850558

RSC4
Chromatin structure-remodeling complex subunit RSC4

7

20

Small-scale

0.745

High

763927

SPT10
Protein SPT10

2

2

High-throughput

0.737

High

850560

HOS3
Histone deacetylase HOS3

2

5

High-throughput

0.737

High

850585

RSC3
Chromatin structure-remodeling complex protein RSC3

6

1

Small-scale

0.736

High

850550

RT102
Regulator of Ty1 transposition protein 102

6

1

High-throughput

0.735

High

850561

RSC9
Chromatin structure-remodeling complex subunit RSC9

9

0

Small-scale

0.722

High

850576

ARP9
Actin-like protein ARP9

5

18

High-throughput

0.718

High

850590

RSC58
Chromatin structure-remodeling complex protein RSC58

8

0

Small-scale

0.716

High

850611

HTL1
High temperature lethal protein 1

8

0

Small-scale

0.716

High

796027

LDB7
Chromatin structure-remodeling complex protein RSC14

2

0

Small-scale

0.716

High

850549

RSC1
Chromatin structure-remodeling complex subunit RSC1

5

20

Small-scale

0.712

High

382174

H4
Histone H4

5

4

Small-scale

0.709

High

850554

H3
Histone H3

5

13

Small-scale

0.706

High

803989

RSC30
Chromatin structure-remodeling complex protein RSC30

4

1

Small-scale

0.686

High

524330

HSP71
Heat shock protein SSA1

4

5

High-throughput

0.672

High

649981

SIN3
Transcriptional regulatory protein SIN3

3

4

High-throughput

0.657

High

643648

SNF2
Transcription regulatory protein SNF2

1

20

Small-scale

0.656

High

850573

POB3
FACT complex subunit POB3

3

2

High-throughput

0.633

High

402227

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

4

High-throughput

0.621

High

794189

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

2

20

High-throughput

0.621

High

820421

RT106
Histone chaperone RTT106

2

1

Small-scale

0.619

High

850578

IMB1
Importin subunit beta-1

2

3

High-throughput

0.612

High

647151

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

3

High-throughput

0.611

High

850600

SCC1
Sister chromatid cohesion protein 1

2

2

Small-scale

0.611

High

545318

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

850575

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

2

8

High-throughput

0.601

High

739673

SPT16
FACT complex subunit SPT16

2

1

High-throughput

0.594

High

547877

NHP6B
Non-histone chromosomal protein 6B

2

14

High-throughput

0.588

High

682925

MSH2
DNA mismatch repair protein MSH2

2

1

High-throughput

0.588

High

850544

RFX1
RFX-like DNA-binding protein RFX1

2

3

High-throughput

0.588

High

850563

NHP10
Non-histone protein 10

2

13

High-throughput

0.588

High

850567

MSH6
DNA mismatch repair protein MSH6

2

1

High-throughput

0.588

High

822992

ATAD2
ATPase histone chaperone YTA7

2

2

Small-scale

0.584

High

826599

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

740419

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

Small-scale

0.576

High

550060

RAP1
DNA-binding protein RAP1

1

1

High-throughput

0.575

High

643272

BAS1
Myb-like DNA-binding protein BAS1

1

10

High-throughput

0.575

High

381148

H2B1
Histone H2B.1

2

16

High-throughput

0.571

High

757766

SAS3
Histone acetyltransferase SAS3

2

1

High-throughput

0.571

High

850577

SWR1
Helicase SWR1

2

20

High-throughput

0.571

High

850609

H2AZ
Histone H2A.Z

2

11

High-throughput

0.571

High

727128

HS104
Heat shock protein 104

2

0

High-throughput

0.569

High

548779

MCM1
Pheromone receptor transcription factor

2

1

High-throughput

0.552

High

676648

SGF29
SAGA complex subunit SGF29

1

6

High-throughput

0.536

High

793941

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

17

High-throughput

0.536

High

850548

SGF73
SAGA complex subunit SGF73

1

5

High-throughput

0.536

High

850559

ABF2
ARS-binding factor 2, mitochondrial

1

17

High-throughput

0.536

High

850568

HMO1
High mobility group protein 1

1

15

High-throughput

0.536

High

850601

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

High-throughput

0.536

High

713275

MCM5
Minichromosome maintenance protein 5

2

0

High-throughput

0.528

High

748136

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.513

High

850371

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.513

High

850542

CLA4
Serine/threonine-protein kinase CLA4

1

2

Small-scale

0.501

High

850564

STE20
Serine/threonine-protein kinase STE20

1

4

Small-scale

0.501

High

741826

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.500

High

849796

EPL1
Enhancer of polycomb-like protein 1

1

0

High-throughput

0.493

High

427331

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.489

High

381547

H2B2
Histone H2B.2

1

16

High-throughput

0.479

High

419783

H2A2
Histone H2A.2

1

11

High-throughput

0.479

High

435176

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

441173

KAPA
cAMP-dependent protein kinase type 1

1

2

Small-scale

0.479

High

448980

TOP2
DNA topoisomerase 2

1

2

High-throughput

0.479

High

452741

ADR1
Regulatory protein ADR1

1

1

High-throughput

0.479

High

561490

TBP
TATA-box-binding protein

1

3

High-throughput

0.479

High

594433

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

647792

RFA1
Replication factor A protein 1

1

2

Small-scale

0.479

High

707437

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

734439

BTAF1
TATA-binding protein-associated factor MOT1

1

20

Small-scale

0.479

High

735037

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

744313

CHD1
Chromo domain-containing protein 1

1

15

High-throughput

0.479

High

745788

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

747918

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

763341

TAF14
Transcription initiation factor TFIID subunit 14

1

5

Small-scale

0.479

High

764102

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

776602

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.479

High

777070

BDF1
Bromodomain-containing factor 1

1

20

High-throughput

0.479

High

778390

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

779269

CENPA
Histone H3-like centromeric protein CSE4

1

13

High-throughput

0.479

High

792109

GBLP
Small ribosomal subunit protein RACK1

1

13

High-throughput

0.479

High

801005

RFC1
Replication factor C subunit 1

1

2

High-throughput

0.479

High

850060

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

850551

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

850552

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

850555

CTF4
DNA polymerase alpha-binding protein

1

8

High-throughput

0.479

High

850569

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

850570

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

850582

PDP3
NuA3 HAT complex component PDP3

1

1

High-throughput

0.479

High

850588

BDF2
Bromodomain-containing factor 2

1

18

High-throughput

0.479

High

850592

MED7
Mediator of RNA polymerase II transcription subunit 7

1

3

Small-scale

0.479

High

850593

YNG1
Protein YNG1

1

4

Small-scale

0.479

High

850595

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.479

High

850599

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

850602

NTO1
NuA3 HAT complex component NTO1

1

1

High-throughput

0.479

High

850606

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

850608

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.479

High

850610

SMC6
Structural maintenance of chromosomes protein 6

1

4

High-throughput

0.479

High

688753

RFA2
Replication factor A protein 2

1

1

High-throughput

0.470

High

641436

RCC1
Guanine nucleotide exchange factor SRM1

1

0

Small-scale

0.458

High

670857

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

850571

IOC4
ISWI one complex protein 4

1

0

High-throughput

0.458

High

850572

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

850579

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

850580

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

850583

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

850594

SGO1
Shugoshin

1

0

High-throughput

0.458

High

850598

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.458

High

392929

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

448186

HAP2
Transcriptional activator HAP2

1

4

High-throughput

0.445

High

488966

SWI6
Regulatory protein SWI6

1

2

High-throughput

0.445

High

547807

NHP6A
Non-histone chromosomal protein 6A

1

13

High-throughput

0.445

High

645617

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

671534

SWI4
Regulatory protein SWI4

1

2

High-throughput

0.445

High

736667

ASF1
Histone chaperone ASF1

1

3

High-throughput

0.445

High

737637

HIR1
Protein HIR1

1

13

High-throughput

0.445

High

738753

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

1

High-throughput

0.445

High

752974

IXR1
Intrastrand cross-link recognition protein

1

13

High-throughput

0.445

High

754162

MSN2
Zinc finger protein MSN2

1

7

High-throughput

0.445

High

754217

MSN4
Zinc finger protein MSN4

1

6

High-throughput

0.445

High

762977

SPT7
SAGA complex subunit SPT7

1

20

High-throughput

0.445

High

781756

SET3
SET domain-containing protein 3

1

8

High-throughput

0.445

High

805550

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

5

High-throughput

0.445

High

819078

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

850539

TAF1
Transcription initiation factor TFIID subunit 1

1

2

High-throughput

0.445

High

850540

TEA1
TY1 enhancer activator

1

4

High-throughput

0.445

High

850546

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

High-throughput

0.445

High

850565

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

5

High-throughput

0.445

High

850566

GIS1
Transcriptional activator/repressor GIS1

1

4

High-throughput

0.445

High

850574

RCO1
Transcriptional regulatory protein RCO1

1

14

High-throughput

0.445

High

850597

HFI1
SAGA complex subunit HFI1

1

2

High-throughput

0.445

High

850607

CAF1A
Chromatin assembly factor 1 subunit A

1

3

High-throughput

0.445

High

757709

EDE1
EH domain-containing and endocytosis protein 1

1

1

High-throughput

0.439

High

149827

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

383762

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

410199

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433706

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

436029

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

441981

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

455124

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

503109

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504276

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512505

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513076

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514692

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

579608

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.437

High

674692

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

689525

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

747436

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

753437

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

795420

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.437

High

802238

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

850543

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

850547

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.437

High

850556

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

850596

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

850603

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

570808

ABF1
ARS-binding factor 1

1

0

High-throughput

0.426

High

756608

MKS1
Negative regulator of RAS-cAMP pathway

1

0

High-throughput

0.426

High

850553

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

394674

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

453657

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

592331

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

813785

GEM1
Mitochondrial Rho GTPase 1

1

1

High-throughput

0.407

High

836757

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

850586

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

850587

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

1

High-throughput

0.407

High

850557

MRS2
Magnesium transporter MRS2, mitochondrial

1

0

High-throughput

0.251

Low

850605

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.251

Low

654790

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.249

Low

825738

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.249

Low

850589

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

850591

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.249

Low

571035

CHS2
Chitin synthase 2

1

0

High-throughput

0.232

Low

811566

MNN9
Mannan polymerase complexes subunit MNN9

1

0

High-throughput

0.232

Low

825586

ICE2
Protein ICE2

1

0

High-throughput

0.232

Low

850541

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

850545

CCH1
Calcium-channel protein CCH1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025