HitPredict

Interactor 1: AGTR1 (P30556)
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Gene: AGTR1

Interactor 2: APJ (P35414)
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Gene: APLNR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 22935142, 21412239
Identification Methods anti bait coimmunoprecipitation, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~7tm_1
Common GO terms GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007204 - positive regulation of cytosolic calcium ion concentration
GO:0007420 - brain development
and 7 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 359
Hs

1 380
+ Hs
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024