HitPredict

Interactor 1: CLIP1 (P30622)
CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)
Gene: CLIP1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12110184
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005938 - cell cortex GO:0031116 - positive regulation of microtubule polymerization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1438 Hs			1 192
+	Hs
		675144 CLIP1_HUMAN (1-1438): 1.12e-138: 464: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		675147 CLIP1_HUMAN (1-1438): 1.12e-138: 464: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Mm
		823530 CTRO_MOUSE (838-1334): 4.44e-19: 96.6: 13.39		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		724757 MYH9_HUMAN (1037-1435): 1.31e-16: 88.4: 9.05		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925322 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564553 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Mm
		823529 CTRO_MOUSE (838-1334): 4.44e-19: 96.6: 13.39		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Hs
		545414 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Mm
		823539 CTRO_MOUSE (838-1334): 4.44e-19: 96.6: 13.39		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Hs
		1113848 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		724776 MYH9_HUMAN (1037-1435): 1.31e-16: 88.4: 9.05		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		892403 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		951040 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894079 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		551652 DESP_HUMAN (582-1355): 2.13e-14: 81.3: 21.07		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Rn
		92842 CTRO_RAT (317-819): 2.5e-15: 84.3: 14.01		RHOA_RAT (5-192): 1.43e-77: 231: 57.98
+	Hs
		900534 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		725138 MYH10_HUMAN (140-652): 5.54e-12: 73: 9.91		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		436338 GRDN_HUMAN (846-1414): 1.77e-15: 84.5: 11.03		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		725125 MYH10_HUMAN (140-652): 5.54e-12: 73: 9.91		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31