Protein: TR10A
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)

Gene: TR10A, TNFRSF10A
Organism: Homo sapiens
Interactions: 134
UniProt ID: O00220

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005035 - death receptor activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127674

FADD
FAS-associated death domain protein

13

20

Small-scale

0.977

High

127612

TR10B
Tumor necrosis factor receptor superfamily member 10B

5

16

Small-scale

0.927

High

127650

TNF10
Tumor necrosis factor ligand superfamily member 10

5

20

Small-scale

0.908

High

127678

CASP8
Caspase-8

17

16

Small-scale

0.763

High

127614

CFLAR
CASP8 and FADD-like apoptosis regulator

5

16

Small-scale

0.699

High

127634

FGFR4
Fibroblast growth factor receptor 4

1

12

High-throughput

0.691

High

127635

FGFR3
Fibroblast growth factor receptor 3

1

12

High-throughput

0.691

High

127637

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.691

High

127641

CD70
CD70 antigen

1

1

High-throughput

0.691

High

127645

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

4

High-throughput

0.691

High

127694

BT2A1
Butyrophilin subfamily 2 member A1

1

3

High-throughput

0.691

High

127710

BT2A2
Butyrophilin subfamily 2 member A2

1

3

High-throughput

0.691

High

127620

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

0

High-throughput

0.656

High

127609

SDCB1
Syntenin-1

2

1

High-throughput

0.628

High

127625

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

7

High-throughput

0.628

High

127643

BMR1A
Bone morphogenetic protein receptor type-1A

2

8

High-throughput

0.628

High

127657

MFAP3
Microfibril-associated glycoprotein 3

2

1

High-throughput

0.628

High

127698

LRP10
Low-density lipoprotein receptor-related protein 10

2

2

High-throughput

0.628

High

127700

FBX11
F-box only protein 11

2

1

High-throughput

0.628

High

127730

CD320
CD320 antigen

2

2

High-throughput

0.628

High

127735

S12A4
Solute carrier family 12 member 4

2

6

High-throughput

0.628

High

127619

BCL10
B-cell lymphoma/leukemia 10

1

2

Small-scale

0.621

High

127642

BASI
Basigin

1

6

High-throughput

0.618

High

127679

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

9

Small-scale

0.618

High

127703

CARME
Carnosine N-methyltransferase

2

0

High-throughput

0.602

High

127682

CEGT
Ceramide glucosyltransferase

2

1

High-throughput

0.574

High

127696

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

1

High-throughput

0.574

High

127676

CUL3
Cullin-3

2

6

Small-scale

0.571

High

127711

CASPA
Caspase-10

2

16

Small-scale

0.571

High

127611

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.536

High

127615

ADCY6
Adenylate cyclase type 6

1

1

High-throughput

0.536

High

127618

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.536

High

127623

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.536

High

127632

INAR1
Interferon alpha/beta receptor 1

1

5

High-throughput

0.536

High

127638

IL4RA
Interleukin-4 receptor subunit alpha

1

4

High-throughput

0.536

High

127639

AVR2A
Activin receptor type-2A

1

8

High-throughput

0.536

High

127644

TGFR2
TGF-beta receptor type-2

1

8

High-throughput

0.536

High

127647

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

4

High-throughput

0.536

High

127651

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.536

High

127659

S10AA
Protein S100-A10

1

3

High-throughput

0.536

High

127665

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

127667

AT11A
Phospholipid-transporting ATPase IH

1

3

High-throughput

0.536

High

127668

EM55
55 kDa erythrocyte membrane protein

1

1

High-throughput

0.536

High

127669

ACVR1
Activin receptor type-1

1

8

High-throughput

0.536

High

127670

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.536

High

127675

SQSTM
Sequestosome-1

1

4

Small-scale

0.536

High

127689

STEA3
Metalloreductase STEAP3

1

1

High-throughput

0.536

High

127691

TM214
Transmembrane protein 214

1

3

High-throughput

0.536

High

127692

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.536

High

127699

LAP4B
Lysosomal-associated transmembrane protein 4B

1

2

High-throughput

0.536

High

127704

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

127706

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

1

High-throughput

0.536

High

127714

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

127715

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.536

High

127721

CDC6
Cell division control protein 6 homolog

1

7

High-throughput

0.536

High

127722

MEP50
Methylosome protein WDR77

1

2

High-throughput

0.536

High

127723

NFIP1
NEDD4 family-interacting protein 1

1

1

High-throughput

0.536

High

127732

GPC5B
G-protein coupled receptor family C group 5 member B

1

4

High-throughput

0.536

High

127737

S4A7
Sodium bicarbonate cotransporter 3

1

3

High-throughput

0.536

High

127688

MARH8
E3 ubiquitin-protein ligase MARCHF8

2

6

Small-scale

0.533

High

71674

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.513

High

127613

GLYG2
Glycogenin-2

1

0

High-throughput

0.513

High

127628

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.513

High

127630

CD44
CD44 antigen

1

0

High-throughput

0.513

High

127653

GALK1
Galactokinase

1

0

High-throughput

0.513

High

127662

1433G
14-3-3 protein gamma

1

0

High-throughput

0.513

High

127684

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

127693

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

127697

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.513

High

127724

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

127733

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.513

High

127736

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.513

High

127718

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

2

Small-scale

0.506

High

127652

RT29
Small ribosomal subunit protein mS29

1

1

Small-scale

0.504

High

64568

MP3B2
Microtubule-associated protein 1 light chain 3 beta 2

1

1

High-throughput

0.489

High

127617

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.489

High

127622

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

127646

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.489

High

127649

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.489

High

127656

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

5

High-throughput

0.489

High

127671

TMM94
Transmembrane protein 94

1

1

High-throughput

0.489

High

127672

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.489

High

127683

LSM12
Protein LSM12

1

1

High-throughput

0.489

High

127686

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

127701

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.489

High

127702

LRC47
Leucine-rich repeat-containing protein 47

1

1

High-throughput

0.489

High

127705

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.489

High

127713

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.489

High

127717

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.489

High

127731

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

127734

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.489

High

126351

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

127621

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

12

High-throughput

0.479

High

127624

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

127627

UBL4A
Ubiquitin-like protein 4A

1

10

High-throughput

0.479

High

127629

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

127631

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

127633

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

7

Small-scale

0.479

High

127636

CBL
E3 ubiquitin-protein ligase CBL

1

9

Small-scale

0.479

High

127655

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

127658

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

127660

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

127661

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

127663

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

127664

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

127666

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

127673

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

127680

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

127695

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

127707

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

6

Small-scale

0.479

High

127728

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

127729

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

127719

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.458

High

127685

Q5HY81
Ubiquitin-like protein 4A

1

10

High-throughput

0.445

High

127690

OTU7B
OTU domain-containing protein 7B

1

7

Small-scale

0.445

High

127720

NP1L4
Nucleosome assembly protein 1-like 4

1

3

High-throughput

0.437

High

71664

A8MXH2
Nucleosome assembly protein 1 like 4

1

3

High-throughput

0.407

High

127640

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.407

High

127648

LSS
Lanosterol synthase

2

0

High-throughput

0.328

High

127687

PR15B
Protein phosphatase 1 regulatory subunit 15B

2

0

High-throughput

0.288

High

91738

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

0

High-throughput

0.279

Low

127610

ABCD4
Lysosomal cobalamin transporter ABCD4

1

0

High-throughput

0.279

Low

127616

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

127654

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.279

Low

127677

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

127681

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.279

Low

127708

ST7L
Suppressor of tumorigenicity 7 protein-like

1

0

High-throughput

0.279

Low

127709

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

127712

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

0

High-throughput

0.279

Low

127716

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.279

Low

127725

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.279

Low

127726

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.279

Low

127727

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

127626

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025