HitPredict

Interactor 1: PSB7 (P30657)
Proteasome subunit beta type-7 (Macropain subunit PRE4) (Multicatalytic endopeptidase complex subunit PRE4) (Proteasome component PRE4) (Proteinase YSCE subunit PRE4)
Gene: PRE4

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	11805826, 19412159, 37968396, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 266 Sc			1 338
+	Sc
		771389 PSA4_YEAST (8-254): 5.24e-78: 238: 12.35		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Sc
		689214 PSA5_YEAST (10-258): 9e-78: 237: 13.95		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Dm
		640776 PSA5_DROME (10-255): 4.32e-81: 245: 15.63		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		638089 PSA4_HUMAN (7-251): 1.11e-80: 245: 11.95		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		849173 PSA6_HUMAN (6-257): 4.66e-81: 245: 11.67		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		656177 PSA5_HUMAN (10-254): 7.52e-80: 242: 13.44		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640791 PSB4_DROME (14-261): 2.83e-71: 221: 35.48		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		594483 PSB1_HUMAN (17-237): 9.08e-70: 216: 19.03		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		640794 Q9VUJ1_DROME (20-251): 3.12e-57: 185: 15.95		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640768 PSB1_DROME (35-243): 2.25e-57: 184: 19.44		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Dm
		640788 Q9VJJ0_DROME (43-249): 4.37e-56: 180: 15.94		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sp
		784779 PSB7_SCHPO (8-266): 4.18e-90: 269: 45.77		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784781 PSA5_SCHPO (10-249): 2.3e-81: 246: 17.21		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784767 PSA3_SCHPO (7-258): 4.14e-78: 238: 12.69		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		1278634 PSA5_DROME (10-255): 4.32e-81: 245: 15.63		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		1358673 PSB4_DROME (14-261): 2.83e-71: 221: 35.48		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Mm
		192889 PSB4_MOUSE (28-261): 3.17e-83: 251: 43.59		PSDE_MOUSE (6-142): 4.74e-27: 109: 24.65
+	Dm
		1358675 Q9VUJ1_DROME (20-251): 3.12e-57: 185: 15.95		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	At
		790140 PSB1_ARATH (40-237): 3.27e-58: 186: 14.56		CSN5A_ARATH (6-160): 3.69e-47: 164: 20.63
+	Dm
		771410 PSB1_DROME (35-243): 2.25e-57: 184: 19.44		PSDE_DROME (3-264): 6.45e-48: 165: 16.90