HitPredict

Interactor 1: GRM5 (P31424)
Metabotropic glutamate receptor 5 (mGluR5)
Gene: GRM5

Interactor 2: GRASP (Q8R4T5)
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) (95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein) (PSD-95 PDZ domain-containing protein) (Tamalin)
Gene: Tamalin

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	11850456, 17396155
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, x-ray crystallography, two hybrid, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030165 - PDZ domain binding GO:0045211 - postsynaptic membrane GO:0098685 - Schaffer collateral - CA1 synapse GO:0098978 - glutamatergic synapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1203 Rn			1 394
+	Hs
		783781 GRM5_HUMAN (15-1203): 0: 1170: 94.24		GRASP_HUMAN (1-394): 5.38e-95: 291: 90.13
+	Rn
		616095 GRM1_RAT (2-1203): 0: 1057: 59.27		GRASP_RAT (1-394): 9.35e-106: 318: 100.00
+	Hs
		1029210 GRM1_HUMAN (3-1203): 0: 1056: 59.35		GRASP_HUMAN (1-394): 5.38e-95: 291: 90.13
+	Rn
		680339 GRM5_RAT (15-1203): 0: 1241: 100.00		SHAN3_RAT (99-334): 6.54e-15: 78.7: 20.24
+	Mm
		1113346 GRM5_MOUSE (15-1203): 0: 1239: 98.99		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Rn
		291492 GRM5_RAT (15-1203): 0: 1241: 100.00		MAGI2_RAT (51-249): 7.52e-09: 59.7: 17.56
+	Rn
		680330 GRM3_RAT (1-877): 0: 832: 40.56		GRASP_RAT (1-394): 9.35e-106: 318: 100.00
+	Rn
		680327 GRM2_RAT (18-859): 0: 795: 42.59		GRASP_RAT (1-394): 9.35e-106: 318: 100.00
+	Hs
		153920 GRM3_HUMAN (1-877): 0: 822: 41.01		NHRF1_HUMAN (88-263): 8.7e-27: 111: 22.73
+	Mm
		1116159 GRM3_MOUSE (1-877): 0: 829: 40.78		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Hs
		153918 GRM2_HUMAN (18-878): 0: 792: 41.91		NHRF1_HUMAN (88-263): 8.7e-27: 111: 22.73
+	Mm
		1061832 GRM2_MOUSE (18-878): 0: 796: 42.14		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Mm
		1116169 GABR1_MOUSE (17-907): 1.05e-132: 431: 15.91		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Hs
		1028142 NMDE2_HUMAN (85-934): 5.34e-106: 368: 11.18		MAGI3_HUMAN (14-362): 2.85e-17: 86.2: 13.60