HitPredict

Interactor 1: TIA1 (P31483)
Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)
Gene: TIA1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 386 Hs			1 768
+	Hs
		963517 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		680449 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		516505 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		963518 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		963519 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1031317 PABP4_HUMAN (1-98): 1.32e-20: 95.5: 21.43		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		680446 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		680447 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		963515 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		963516 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		680474 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		516506 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		516507 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1031318 PABP4_HUMAN (1-98): 1.32e-20: 95.5: 21.43		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		963558 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		516503 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		516504 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1031315 PABP4_HUMAN (1-98): 1.32e-20: 95.5: 21.43		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1031316 PABP4_HUMAN (1-98): 1.32e-20: 95.5: 21.43		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		516626 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		CUL5_HUMAN (25-768): 0: 597: 23.77