Protein: HELLS
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)

Gene: HELLS
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q9NRZ9

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0001655 - urogenital system development
GO:0001822 - kidney development
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935281

H31
Histone H3.1

3

20

High-throughput

0.827

High

918719

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1334028

WDR76
WD repeat-containing protein 76

6

20

Small-scale

0.738

High

123327

CBX4
E3 SUMO-protein ligase CBX4

1

20

High-throughput

0.691

High

323193

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

20

High-throughput

0.675

High

348000

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.656

High

455912

PARP1
Poly [ADP-ribose] polymerase 1

3

20

Small-scale

0.640

High

1270466

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.640

High

1038748

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.624

High

545176

PVR
Poliovirus receptor

1

1

High-throughput

0.618

High

261020

H2AY
Core histone macro-H2A.1

1

20

Small-scale

0.618

High

828391

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

892918

IF4A1
Eukaryotic initiation factor 4A-I

1

15

Small-scale

0.618

High

918003

H4
Histone H4

1

19

High-throughput

0.618

High

952651

H33
Histone H3.3

1

20

High-throughput

0.618

High

976519

ERCC6
DNA excision repair protein ERCC-6

1

19

Small-scale

0.618

High

1027286

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1059895

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.618

High

1313180

DDX23
Probable ATP-dependent RNA helicase DDX23

1

18

High-throughput

0.618

High

1331247

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

15

High-throughput

0.618

High

1345260

HELLS
Lymphoid-specific helicase

1

17

Small-scale

0.618

High

527826

LAMP2
Lysosome-associated membrane glycoprotein 2

3

1

High-throughput

0.613

High

1345261

S39A9
Zinc transporter ZIP9

2

0

High-throughput

0.602

High

1048985

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.580

High

771248

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.578

High

1135846

DCAF8
DDB1- and CUL4-associated factor 8

1

20

Small-scale

0.578

High

341294

FA9
Coagulation factor IX

2

3

High-throughput

0.574

High

1083496

C3AR
C3a anaphylatoxin chemotactic receptor

2

2

High-throughput

0.574

High

135292

E2F3
Transcription factor E2F3

1

9

Small-scale

0.569

High

387588

P53
Cellular tumor antigen p53

1

10

Small-scale

0.561

High

559968

H12
Histone H1.2

1

10

Small-scale

0.561

High

641288

DNMT1
DNA

1

20

Small-scale

0.561

High

1303051

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

18

Small-scale

0.561

High

1345267

DNM3B
DNA

1

10

Small-scale

0.561

High

1328718

GTSFL
Gametocyte-specific factor 1-like

2

1

High-throughput

0.553

High

1171892

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

71254

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

14

High-throughput

0.536

High

126480

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

452487

PGFRB
Platelet-derived growth factor receptor beta

1

10

High-throughput

0.536

High

502596

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.536

High

639095

S100P
Protein S100-P

1

11

High-throughput

0.536

High

796033

MAGA8
Melanoma-associated antigen 8

1

8

High-throughput

0.536

High

796184

MAGA9
Melanoma-associated antigen 9

1

8

High-throughput

0.536

High

877638

FOXG1
Forkhead box protein G1

1

20

High-throughput

0.536

High

878010

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.536

High

1021359

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.536

High

1039876

SNW1
SNW domain-containing protein 1

1

9

High-throughput

0.536

High

1061268

NUMA1
Nuclear mitotic apparatus protein 1

1

12

High-throughput

0.536

High

1075257

TEAD2
Transcriptional enhancer factor TEF-4

1

8

High-throughput

0.536

High

1246042

NEDD1
Protein NEDD1

1

13

High-throughput

0.536

High

1295909

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

4

High-throughput

0.536

High

1302172

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.536

High

1303786

CDC5L
Cell division cycle 5-like protein

1

20

High-throughput

0.536

High

1318645

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

1345273

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.536

High

1345270

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

4

High-throughput

0.515

High

263844

PR40A
Pre-mRNA-processing factor 40 homolog A

1

19

High-throughput

0.515

High

877152

CASP6
Caspase-6

1

5

High-throughput

0.515

High

919283

RAN
GTP-binding nuclear protein Ran

1

11

High-throughput

0.515

High

1151261

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.515

High

1318394

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

172242

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

196874

CYB5B
Cytochrome b5 type B

1

3

High-throughput

0.489

High

456947

FURIN
Furin

1

1

High-throughput

0.489

High

661458

S10A2
Protein S100-A2

1

11

High-throughput

0.489

High

1062682

EMC2
ER membrane protein complex subunit 2

1

8

High-throughput

0.489

High

1067626

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1284821

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.489

High

1306441

CML1
Chemerin-like receptor 1

1

2

High-throughput

0.489

High

1318978

SEM4C
Semaphorin-4C

1

4

High-throughput

0.489

High

1345264

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.489

High

1345266

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.489

High

1345272

ANR50
Ankyrin repeat domain-containing protein 50

1

5

High-throughput

0.489

High

838303

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

48138

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

2

Small-scale

0.479

High

158860

HAT1
Histone acetyltransferase type B catalytic subunit

1

3

Small-scale

0.479

High

228826

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

239412

CC14B
Dual specificity protein phosphatase CDC14B

1

4

High-throughput

0.479

High

244991

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

278878

DNJC8
DnaJ homolog subfamily C member 8

1

5

High-throughput

0.479

High

339029

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

360457

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

377722

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

385581

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

489300

H14
Histone H1.4

1

10

Small-scale

0.479

High

524032

XRCC6
X-ray repair cross-complementing protein 6

1

13

Small-scale

0.479

High

538045

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

553828

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

559263

H15
Histone H1.5

1

14

Small-scale

0.479

High

559509

H13
Histone H1.3

1

10

Small-scale

0.479

High

570106

CEBPB
CCAAT/enhancer-binding protein beta

1

19

High-throughput

0.479

High

595436

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

603746

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

6

High-throughput

0.479

High

607174

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.479

High

652364

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

11

High-throughput

0.479

High

653004

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

669003

PML
Protein PML

1

17

High-throughput

0.479

High

685047

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

738276

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

9

High-throughput

0.479

High

750490

COIL
Coilin

1

8

High-throughput

0.479

High

780171

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

795923

MAGA6
Melanoma-associated antigen 6

1

8

High-throughput

0.479

High

839830

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.479

High

858339

TXTP
Tricarboxylate transport protein, mitochondrial

1

4

High-throughput

0.479

High

862481

ACLY
ATP-citrate synthase

1

2

Small-scale

0.479

High

875351

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

896384

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

2

Small-scale

0.479

High

896549

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.479

High

932583

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

Small-scale

0.479

High

944454

PRKDC
DNA-dependent protein kinase catalytic subunit

1

14

Small-scale

0.479

High

971367

H11
Histone H1.1

1

10

Small-scale

0.479

High

999130

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1042629

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1043248

CUL4A
Cullin-4A

1

12

Small-scale

0.479

High

1043609

CUL4B
Cullin-4B

1

12

Small-scale

0.479

High

1064759

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1066756

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1067158

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1080387

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

1082413

DDB1
DNA damage-binding protein 1

1

8

Small-scale

0.479

High

1138823

MYSM1
Deubiquitinase MYSM1

1

20

Small-scale

0.479

High

1188919

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.479

High

1200690

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1201921

TAXB1
Tax1-binding protein 1

1

12

High-throughput

0.479

High

1221763

SMC5
Structural maintenance of chromosomes protein 5

1

16

High-throughput

0.479

High

1224802

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.479

High

1243955

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1264199

DNJC9
DnaJ homolog subfamily C member 9

1

4

High-throughput

0.479

High

1266362

H1X
Histone H1.10

1

2

Small-scale

0.479

High

1281416

FBXW7
F-box/WD repeat-containing protein 7

1

10

High-throughput

0.479

High

1281854

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1330856

Q9H4D1
Protein kinase

1

3

High-throughput

0.479

High

1345263

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1345265

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

Small-scale

0.479

High

1345269

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1345271

TEKT2
Tektin-2

1

2

High-throughput

0.479

High

1345274

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.479

High

1345275

SMC3
Structural maintenance of chromosomes protein 3

1

10

High-throughput

0.479

High

1345276

ZN330
Zinc finger protein 330

1

6

High-throughput

0.479

High

307278

RCBT2
RCC1 and BTB domain-containing protein 2

1

2

High-throughput

0.470

High

921442

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1221371

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

395871

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

217951

PRKY
Putative serine/threonine-protein kinase PRKY

1

4

High-throughput

0.445

High

1130635

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

179843

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

12

High-throughput

0.437

High

283043

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.437

High

548129

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

1

Small-scale

0.437

High

721555

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

830799

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.437

High

922416

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.437

High

1002073

ARL16
ADP-ribosylation factor-like protein 16

1

3

High-throughput

0.437

High

1174005

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

11

Small-scale

0.437

High

1206073

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.437

High

1222593

SLX4
Structure-specific endonuclease subunit SLX4

1

17

High-throughput

0.437

High

1328260

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.437

High

1329095

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.437

High

1331394

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

1332501

RPAP3
RNA polymerase II-associated protein 3

1

11

High-throughput

0.437

High

1335330

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.437

High

1345262

DJC17
DnaJ homolog subfamily C member 17

1

12

High-throughput

0.437

High

831719

CEBPA
CCAAT/enhancer-binding protein alpha

1

18

High-throughput

0.408

High

310355

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

1198444

T150A
Transmembrane protein 150A

2

0

High-throughput

0.318

High

1261338

TM171
Transmembrane protein 171

2

0

High-throughput

0.318

High

296225

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

High-throughput

0.279

Low

362293

GLPA
Glycophorin-A

1

0

High-throughput

0.279

Low

1134306

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1183422

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.279

Low

1288419

NXPE2
NXPE family member 2

1

0

High-throughput

0.279

Low

1334379

CHODL
Chondrolectin

1

0

High-throughput

0.279

Low

1345268

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

413167

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

81766

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

1165988

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024