HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.765

The method score is based on:

Property Details
Experiments 10910062, 14970221, 18566586, 21343617, 23872070, 22084251, 22337773, 26293922, 30639242, 22307628, 29567957, 19299511, 21045808, 15718470, 18566587, 21177249, 18505677, 24670654, 11438723
Identification Methods pull down, unspecified method, enzymatic study, affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation, beta lactamase complementation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 24 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 480
Hs

1 2549
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+ Mm
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+ Rn
+ Sc
+ Sp
+ Hs
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+ Sc

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Last updated: 15 Jul 2024