Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 28205554
Identification Methods fluorescent resonance energy transfer
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 9 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 480
Hs

1 347
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Ce
+ Dm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024