HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18250332
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 2671
+	Hs
		568668 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		681847 AKT1_HUMAN (1-480): 0: 586: 100.00		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Rn
		670511 AKT3_RAT (1-478): 0: 545: 82.29		ITPR1_RAT (2-2663): 0: 3906: 60.98
+	Hs
		568670 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		568667 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		568750 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		RYR2_HUMAN (1712-2183): 2.1e-45: 184: 19.37
+	Hs
		610755 KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86		RYR2_HUMAN (1712-2183): 2.1e-45: 184: 19.37