Protein: LHX4
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)

Gene: LHX4
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q969G2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001890 - placenta development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287917

LDB1
LIM domain-binding protein 1

7

20

High-throughput

0.965

High

1379927

ISL2
Insulin gene enhancer protein ISL-2

6

17

Small-scale

0.947

High

961487

ISL1
Insulin gene enhancer protein ISL-1

5

19

High-throughput

0.928

High

700832

PIT1
Pituitary-specific positive transcription factor 1

2

20

High-throughput

0.783

High

1025222

HXC5
Homeobox protein Hox-C5

2

11

High-throughput

0.783

High

965497

LMO4
LIM domain transcription factor LMO4

2

19

High-throughput

0.754

High

1379978

ORC6
Origin recognition complex subunit 6

5

2

High-throughput

0.717

High

1010767

SSBP2
Single-stranded DNA-binding protein 2

5

20

High-throughput

0.714

High

1379970

MARE3
Microtubule-associated protein RP/EB family member 3

2

2

High-throughput

0.700

High

1379944

SSBP4
Single-stranded DNA-binding protein 4

4

20

High-throughput

0.694

High

1347340

LMO3
LIM domain only protein 3

1

19

High-throughput

0.691

High

1379945

SSBP3
Single-stranded DNA-binding protein 3

4

20

High-throughput

0.691

High

1379943

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

3

1

High-throughput

0.675

High

215847

P52K
52 kDa repressor of the inhibitor of the protein kinase

3

2

High-throughput

0.667

High

1106645

SMAD4
Mothers against decapentaplegic homolog 4

3

3

High-throughput

0.667

High

1316691

ABI1
Abl interactor 1

3

11

High-throughput

0.667

High

1379953

CHM1A
Charged multivesicular body protein 1a

3

2

High-throughput

0.667

High

1379959

ABI2
Abl interactor 2

3

16

High-throughput

0.667

High

223938

LDB2
LIM domain-binding protein 2

1

20

Small-scale

0.656

High

1228267

ARID2
AT-rich interactive domain-containing protein 2

3

20

High-throughput

0.656

High

675614

TYY1
Transcriptional repressor protein YY1

3

15

High-throughput

0.653

High

1379975

T22D4
TSC22 domain family protein 4

2

8

High-throughput

0.628

High

587171

ITF2
Transcription factor 4

1

5

High-throughput

0.621

High

1115578

ASPP2
Apoptosis-stimulating of p53 protein 2

1

16

High-throughput

0.621

High

1032769

SATB1
DNA-binding protein SATB1

1

7

High-throughput

0.618

High

1132668

MEF2D
Myocyte-specific enhancer factor 2D

1

3

High-throughput

0.618

High

1310099

MGAP
MAX gene-associated protein

1

8

High-throughput

0.618

High

1379932

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

14

High-throughput

0.618

High

1379950

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

11

High-throughput

0.618

High

1379961

LHX3
LIM/homeobox protein Lhx3

1

18

Small-scale

0.618

High

1379963

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.618

High

1379965

ZHX1
Zinc fingers and homeoboxes protein 1

1

20

High-throughput

0.618

High

1379969

SATB2
DNA-binding protein SATB2

1

7

High-throughput

0.618

High

1379982

ZHX2
Zinc fingers and homeoboxes protein 2

1

17

High-throughput

0.618

High

1252643

ZN574
Zinc finger protein 574

2

6

High-throughput

0.611

High

1379928

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

2

High-throughput

0.611

High

1329570

CA052
UPF0690 protein C1orf52

3

2

High-throughput

0.609

High

1379981

WASF2
Actin-binding protein WASF2

3

8

High-throughput

0.609

High

478145

SNRPA
U1 small nuclear ribonucleoprotein A

2

1

High-throughput

0.606

High

783736

ZNF76
Zinc finger protein 76

2

10

High-throughput

0.606

High

944201

SCND1
SCAN domain-containing protein 1

2

9

High-throughput

0.606

High

1025286

CDK3
Cyclin-dependent kinase 3

2

2

High-throughput

0.606

High

1180170

QRIC1
Transcriptional regulator QRICH1

2

18

High-throughput

0.606

High

1328892

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

5

High-throughput

0.606

High

1379947

IN80B
INO80 complex subunit B

2

1

High-throughput

0.606

High

1379954

MYOZ1
Myozenin-1

2

2

High-throughput

0.606

High

1379956

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

1

High-throughput

0.606

High

1086180

CETN1
Centrin-1

2

0

High-throughput

0.602

High

1379980

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.601

High

258608

SH21A
SH2 domain-containing protein 1A

2

7

High-throughput

0.600

High

139017

BCL9
B-cell CLL/lymphoma 9 protein

2

20

High-throughput

0.584

High

1289050

BCL9L
B-cell CLL/lymphoma 9-like protein

2

20

High-throughput

0.584

High

783116

ARL2
ADP-ribosylation factor-like protein 2

2

0

High-throughput

0.580

High

1324627

CENPS
Centromere protein S

2

0

High-throughput

0.580

High

288481

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.573

High

1165301

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

4

High-throughput

0.573

High

474184

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

1180798

KLH38
Kelch-like protein 38

2

3

High-throughput

0.553

High

1208942

DCA10
DDB1- and CUL4-associated factor 10

2

1

High-throughput

0.553

High

1280122

SEN54
tRNA-splicing endonuclease subunit Sen54

2

1

High-throughput

0.553

High

1331997

BANP
Protein BANP

2

6

High-throughput

0.553

High

1379933

DHRS1
Dehydrogenase/reductase SDR family member 1

2

1

High-throughput

0.553

High

1379938

COR1B
Coronin-1B

2

1

High-throughput

0.553

High

181150

AXIN1
Axin-1

1

4

High-throughput

0.541

High

1379976

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.536

High

143171

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.515

High

1087920

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

1379971

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

775897

HNF1B
Hepatocyte nuclear factor 1-beta

1

12

High-throughput

0.501

High

1133583

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.501

High

1379942

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

3

High-throughput

0.500

High

1104635

IKZF1
DNA-binding protein Ikaros

1

18

High-throughput

0.481

High

1160982

NRF1
Nuclear respiratory factor 1

1

4

High-throughput

0.481

High

1250277

ATL4
ADAMTS-like protein 4

1

3

High-throughput

0.481

High

1294606

Z354C
Zinc finger protein 354C

1

7

High-throughput

0.481

High

1334110

TXND5
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.481

High

154737

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161501

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174385

ZN609
Zinc finger protein 609

1

11

High-throughput

0.479

High

180889

TIF1A
Transcription intermediary factor 1-alpha

1

10

High-throughput

0.479

High

194597

KDM6A
Lysine-specific demethylase 6A

1

5

High-throughput

0.479

High

278399

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

282763

E2F6
Transcription factor E2F6

1

3

High-throughput

0.479

High

481352

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

559774

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

15

High-throughput

0.479

High

586332

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.479

High

687278

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

770035

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

879335

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

17

High-throughput

0.479

High

903224

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

12

High-throughput

0.479

High

903448

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

13

High-throughput

0.479

High

927470

ATX1
Ataxin-1

1

5

High-throughput

0.479

High

1017461

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.479

High

1024123

TFAM
Transcription factor A, mitochondrial

1

18

High-throughput

0.479

High

1047849

TLE1
Transducin-like enhancer protein 1

1

12

High-throughput

0.479

High

1055627

GABPA
GA-binding protein alpha chain

1

6

High-throughput

0.479

High

1061803

TLE5
TLE family member 5

1

10

High-throughput

0.479

High

1112319

PWP1
Periodic tryptophan protein 1 homolog

1

3

High-throughput

0.479

High

1150402

NCOA2
Nuclear receptor coactivator 2

1

5

High-throughput

0.479

High

1152721

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

1196900

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

8

High-throughput

0.479

High

1219731

ZMYM4
Zinc finger MYM-type protein 4

1

11

High-throughput

0.479

High

1242486

NFRKB
Nuclear factor related to kappa-B-binding protein

1

17

High-throughput

0.479

High

1257094

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

1277199

POGZ
Pogo transposable element with ZNF domain

1

8

High-throughput

0.479

High

1287971

PB1
Protein polybromo-1

1

16

High-throughput

0.479

High

1308712

FOXP4
Forkhead box protein P4

1

14

High-throughput

0.479

High

1317114

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

14

High-throughput

0.479

High

1323527

ZN687
Zinc finger protein 687

1

5

High-throughput

0.479

High

1338264

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1338748

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1340145

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1356496

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1357461

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

8

High-throughput

0.479

High

1368264

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1368346

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1369146

KAT2A
Histone acetyltransferase KAT2A

1

17

High-throughput

0.479

High

1370735

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

1379926

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.479

High

1379929

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

1379934

PHF12
PHD finger protein 12

1

12

High-throughput

0.479

High

1379935

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1379936

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1379937

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

8

High-throughput

0.479

High

1379940

PYGO2
Pygopus homolog 2

1

11

High-throughput

0.479

High

1379941

PCGF1
Polycomb group RING finger protein 1

1

9

High-throughput

0.479

High

1379946

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.479

High

1379948

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

1

High-throughput

0.479

High

1379949

ZN644
Zinc finger protein 644

1

8

High-throughput

0.479

High

1379955

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

1379957

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

1379960

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

7

High-throughput

0.479

High

1379968

TRI33
E3 ubiquitin-protein ligase TRIM33

1

9

High-throughput

0.479

High

1379977

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1379979

NCOR2
Nuclear receptor corepressor 2

1

12

High-throughput

0.479

High

1289408

Q86UY0
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.470

High

1157323

SSX1
Protein SSX1

1

0

Small-scale

0.460

High

261431

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.458

High

961076

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

1098581

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.458

High

1379962

IF172
Intraflagellar transport protein 172 homolog

1

1

Small-scale

0.457

High

299323

FLOT1
Flotillin-1

1

3

High-throughput

0.457

High

839603

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.457

High

300809

KRT38
Keratin, type I cuticular Ha8

1

19

High-throughput

0.439

High

1063496

GOGA2
Golgin subfamily A member 2

1

11

High-throughput

0.439

High

1230180

K1C40
Keratin, type I cytoskeletal 40

1

18

High-throughput

0.439

High

1379966

UBQL1
Ubiquilin-1

1

4

High-throughput

0.439

High

1272190

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

2

High-throughput

0.437

High

1309470

CEP97
Centrosomal protein of 97 kDa

1

2

High-throughput

0.437

High

1379939

CHOLN
Protein cholesin

1

3

High-throughput

0.437

High

1379951

GRPE1
GrpE protein homolog 1, mitochondrial

1

1

High-throughput

0.437

High

1379958

RBM28
RNA-binding protein 28

1

3

High-throughput

0.437

High

1379967

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

1379972

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.437

High

1379973

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

1201021

ACTBL
Beta-actin-like protein 2

1

7

High-throughput

0.407

High

295995

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.316

High

948162

DJB13
DnaJ homolog subfamily B member 13

2

0

High-throughput

0.316

High

1214460

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

2

0

High-throughput

0.316

High

1278381

TRM11
tRNA

2

0

High-throughput

0.316

High

1315513

BD1L2
Biorientation of chromosomes in cell division protein 1-like 2

2

0

High-throughput

0.316

High

1379930

ERO1A
ERO1-like protein alpha

2

0

High-throughput

0.316

High

1379952

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.316

High

1379974

WASC3
WASH complex subunit 3

2

0

High-throughput

0.316

High

1379964

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.279

Low

1242410

FDX2
Ferredoxin-2, mitochondrial

1

0

High-throughput

0.268

Low

185105

TELT
Telethonin

1

0

High-throughput

0.265

Low

1379931

DCAF5
DDB1- and CUL4-associated factor 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025