HitPredict

Interactor 1: HECA2 (A8MVW5)
HEPACAM family member 2 (Mitotic kinetics regulator)
Gene: HEPACAM2

Interactor 2: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 462 Hs			1 728
+	Hs
		68242 HECA2_HUMAN (1-462): 2.38e-97: 302: 100.00		P55G_HUMAN (312-722): 1.53e-103: 326: 71.85
+	Dm
		219802 O44924_DROME (140-461): 6.02e-56: 202: 17.54		ABL_DROME (531-725): 1.27e-32: 138: 20.92
+	Hs
		789014 TUTLB_HUMAN (2-461): 3.54e-51: 188: 14.14		TEC_HUMAN (392-727): 6.13e-31: 130: 14.80
+	Hs
		433507 TUTLB_HUMAN (2-461): 3.54e-51: 188: 14.14		YES_HUMAN (556-728): 9.82e-31: 129: 19.34
+	Hs
		434081 TUTLB_HUMAN (2-461): 3.54e-51: 188: 14.14		LYN_HUMAN (527-724): 1.21e-29: 125: 18.78
+	Hs
		523211 TUTLB_HUMAN (2-461): 3.54e-51: 188: 14.14		SRC_HUMAN (535-728): 1.04e-28: 123: 18.81
+	Hs
		609182 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		P85A_HUMAN (606-721): 5.69e-21: 100: 28.81
+	Hs
		434111 ROBO1_HUMAN (3-462): 2.87e-42: 162: 13.11		LYN_HUMAN (527-724): 1.21e-29: 125: 18.78
+	Hs
		609244 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40
+	Hs
		609260 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		PTN11_HUMAN (622-723): 5.34e-12: 71: 24.56
+	Hs
		523015 CEA21_HUMAN (89-237): 1.08e-42: 154: 28.86		SRC_HUMAN (535-728): 1.04e-28: 123: 18.81
+	Hs
		433569 CD22_HUMAN (38-437): 2.92e-30: 126: 15.71		LYN_HUMAN (527-724): 1.21e-29: 125: 18.78
+	Hs
		434019 ROBO2_HUMAN (235-462): 2.47e-28: 120: 13.88		LYN_HUMAN (527-724): 1.21e-29: 125: 18.78
+	Hs
		433742 PTK7_HUMAN (150-422): 6.91e-27: 116: 16.90		LYN_HUMAN (527-724): 1.21e-29: 125: 18.78
+	Hs
		532367 CEAM1_HUMAN (52-453): 2.61e-45: 167: 14.25		PTN11_HUMAN (622-723): 5.34e-12: 71: 24.56
+	Hs
		590600 CD22_HUMAN (38-437): 2.92e-30: 126: 15.71		P85A_HUMAN (606-721): 5.69e-21: 100: 28.81
+	Mm
		643060 CD22_MOUSE (22-451): 5.67e-25: 110: 13.26		P85A_MOUSE (606-721): 1.27e-20: 98.9: 28.81
+	Hs
		590607 CD22_HUMAN (38-437): 2.92e-30: 126: 15.71		GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40
+	Hs
		985950 PTK7_HUMAN (150-422): 6.91e-27: 116: 16.90		PTN11_HUMAN (622-723): 5.34e-12: 71: 24.56
+	Mm
		682308 CEAM1_MOUSE (30-263): 5.92e-27: 115: 25.51		PTN11_MOUSE (622-723): 5.25e-12: 71: 24.56