HitPredict

Interactor 1: AKT2 (P31751)
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Gene: AKT2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PH, PH~Pkinase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 481 Hs			1 779
+	Hs
		682023 AKT1_HUMAN (1-478): 0: 564: 81.63		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		623884 KPCL_HUMAN (114-478): 7.62e-153: 452: 41.96		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		981062 KPCT_HUMAN (85-481): 9.91e-147: 437: 38.19		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408682 KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		568795 KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1073480 KS6A1_HUMAN (55-456): 2.33e-109: 342: 23.13		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		850712 KS6A3_HUMAN (55-452): 8.73e-107: 335: 23.36		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		270445 KS6A5_HUMAN (60-406): 1.32e-104: 331: 27.25		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		784090 KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566481 KPCA_HUMAN (146-475): 2.81e-103: 324: 47.43		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		681831 AKT1_HUMAN (1-478): 0: 564: 81.63		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (1-481): 0: 540: 76.40		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		969077 KPCE_HUMAN (57-475): 3.59e-147: 439: 39.10		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568704 KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		408612 KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568798 KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		784000 KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		566377 KPCA_HUMAN (146-475): 2.81e-103: 324: 47.43		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		1071703 KS6A2_HUMAN (55-452): 6.02e-107: 335: 23.67		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		299245 KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69