Protein: EI2BA
Translation initiation factor eIF2B subunit alpha (GCD complex subunit GCN3) (Guanine nucleotide exchange factor subunit GCN3) (Translational activator GCN3) (eIF2B GDP-GTP exchange factor subunit alpha)

Gene: EI2BA, GCN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P14741

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005851 - eukaryotic translation initiation factor 2B complex
GO:0006413 - translational initiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575318

EI2BB
Translation initiation factor eIF2B subunit beta

12

13

Small-scale

0.981

High

575317

EI2BE
Translation initiation factor eIF2B subunit epsilon

10

15

Small-scale

0.973

High

555284

EI2BD
Translation initiation factor eIF2B subunit delta

8

14

Small-scale

0.971

High

575302

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

4

4

Small-scale

0.892

High

575292

EI2BA
Translation initiation factor eIF2B subunit alpha

3

13

High-throughput

0.838

High

478387

EI2BG
Translation initiation factor eIF2B subunit gamma

10

15

Small-scale

0.757

High

478581

IF2B
Eukaryotic translation initiation factor 2 subunit beta

5

7

Small-scale

0.714

High

575316

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

4

7

High-throughput

0.697

High

575303

CLH
Clathrin heavy chain

3

0

High-throughput

0.622

High

575338

TCPD
T-complex protein 1 subunit delta

3

2

High-throughput

0.599

High

543673

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.584

High

434776

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.571

High

510145

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.552

High

575311

BMH1
Protein BMH1

2

4

High-throughput

0.543

High

575366

RUVB1
RuvB-like protein 1

2

2

High-throughput

0.543

High

575359

IST1
Vacuolar protein sorting-associated protein IST1

2

2

High-throughput

0.537

High

575347

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.536

High

386549

TBB
Tubulin beta chain

2

2

High-throughput

0.533

High

575298

VATB
V-type proton ATPase subunit B

2

2

High-throughput

0.533

High

575332

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

2

Small-scale

0.521

High

575350

MPG1
Mannose-1-phosphate guanyltransferase

1

11

High-throughput

0.514

High

575310

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

575349

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

575356

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

358953

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

4

High-throughput

0.500

High

359419

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

4

High-throughput

0.500

High

367670

ENO1
Enolase 1

1

2

High-throughput

0.500

High

405010

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.500

High

408279

GAL1
Galactokinase

1

1

High-throughput

0.500

High

408547

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.500

High

420875

PMA1
Plasma membrane ATPase 1

1

2

High-throughput

0.500

High

439218

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

481457

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.500

High

575301

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

575315

EF2
Elongation factor 2

1

2

High-throughput

0.500

High

575341

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.500

High

368219

TRP
Tryptophan synthase

1

1

High-throughput

0.489

High

368313

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

4

High-throughput

0.489

High

575295

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

2

High-throughput

0.489

High

575296

BGL2
Glucan 1,3-beta-glucosidase

1

1

High-throughput

0.489

High

575312

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.489

High

575313

XPO1
Exportin-1

1

10

High-throughput

0.489

High

575322

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

575333

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

1

High-throughput

0.489

High

575339

FKHL1
Pre-rRNA-processing protein FHL1

1

3

High-throughput

0.489

High

575345

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

2

High-throughput

0.489

High

575352

GUF1
Translation factor GUF1, mitochondrial

1

3

High-throughput

0.489

High

454067

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.479

High

554991

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

435735

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

436305

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.479

High

575294

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

575305

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

575327

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

575335

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

575340

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

575357

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

575360

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

575363

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

575370

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

575354

LSM1
LSM1-LSM7 complex subunit LSM1

1

1

High-throughput

0.464

High

575323

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

575362

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

Small-scale

0.458

High

471364

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.457

High

486005

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.457

High

486396

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.457

High

575293

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.457

High

575297

HSP26
Heat shock protein 26

1

5

High-throughput

0.457

High

575299

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.457

High

575308

URA7
CTP synthase 1

1

1

High-throughput

0.457

High

575320

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.457

High

575324

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.457

High

575336

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.457

High

575361

ACT
Actin

1

2

High-throughput

0.457

High

575371

HSP42
Heat shock protein 42

1

5

High-throughput

0.457

High

392138

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.445

High

394179

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

453396

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

522921

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

575321

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

575344

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

575348

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.445

High

575306

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

575309

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

575326

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

575331

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

575364

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

575369

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

364898

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

376176

RAS1
Ras-like protein 1

1

1

High-throughput

0.407

High

575355

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.407

High

575334

BIT2
Probable target of rapamycin complex 2 subunit BIT2

2

0

High-throughput

0.323

High

453043

CBP6
Cytochrome B pre-mRNA-processing protein 6

1

0

High-throughput

0.279

Low

575300

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.279

Low

575325

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.279

Low

575328

PET10
Protein PET10

1

0

High-throughput

0.279

Low

575337

HXT7
High-affinity hexose transporter HXT7

1

0

High-throughput

0.279

Low

575342

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.279

Low

575367

YHM2
Citrate/oxoglutarate carrier protein

1

0

High-throughput

0.279

Low

575314

GLPK
Glycerol kinase

1

0

High-throughput

0.269

Low

575329

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.269

Low

575330

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.269

Low

575307

IPYR2
Inorganic pyrophosphatase, mitochondrial

1

0

High-throughput

0.265

Low

575319

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.265

Low

575343

LSM5
LSM complex subunit LSM5

1

0

High-throughput

0.265

Low

575358

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.265

Low

575365

TMA23
Protein TMA23

1

0

High-throughput

0.265

Low

575304

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

575346

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

575351

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

574847

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low

575353

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

575368

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025