HitPredict

Interactor 1: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12200137
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 509
+	Hs
		1072502 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		SHB_HUMAN (1-509): 5.37e-127: 381: 100.00
+	Hs
		666008 IL2RG_HUMAN (1-369): 6.04e-109: 325: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		682260 IL2RG_HUMAN (1-369): 6.04e-109: 325: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Mm
		403425 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		522803 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		500949 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		666048 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		433265 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		557644 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		500941 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		557643 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412104 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		665574 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		872610 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		924590 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		500956 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		665558 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Mm
		872619 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		ABL2_MOUSE (354-487): 1.65e-35: 143: 26.12
+	Hs
		337360 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		789068 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12