HitPredict

Interactor 1: MP2K1 (P31938)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: Map2k1

Interactor 2: NMDZ1 (P35438)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: Grin1

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	10862698
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0030425 - dendrite GO:0044877 - protein-containing complex binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 393 Mm			1 938
+	Mm
		723589 MP2K2_MOUSE (1-391): 4.84e-123: 362: 78.70		NMDZ1_MOUSE (1-938): 0: 920: 100.00
+	Mm
		682465 MP2K1_MOUSE (1-393): 5.96e-126: 370: 100.00		NMDE2_MOUSE (4-938): 0: 628: 23.86
+	Mm
		963734 MP2K2_MOUSE (1-391): 4.84e-123: 362: 78.70		NMDE2_MOUSE (4-938): 0: 628: 23.86
+	Hs
		625438 CDK2_HUMAN (65-367): 1.51e-126: 368: 24.60		NMDE3_HUMAN (6-924): 0: 601: 22.92
+	Mm
		620958 AKT2_MOUSE (20-393): 2.38e-111: 336: 20.37		GRIA2_MOUSE (3-856): 0: 628: 21.55
+	Hs
		681815 AKT1_HUMAN (23-369): 4.11e-113: 340: 21.05		NMDE1_HUMAN (1-923): 0: 623: 24.11