HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	17353931, 33961781, 35271311, 36931259, 15324660, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1824
+	Hs
		876345 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		66891 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		A8MQ02_HUMAN (43-1824): 0: 1196: 99.44
+	Hs
		66892 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		A8MQ02_HUMAN (43-1824): 0: 1196: 99.44
+	Hs
		910062 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		683742 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Dm
		54781 1433E_DROME (3-245): 4.63e-144: 405: 64.90		A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76
+	Hs
		909583 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		683361 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		231490 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66
+	Hs
		231459 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66
+	Hs
		108805 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		H0Y8L4_HUMAN (1511-1824): 1.15e-44: 166: 98.41
+	Mm
		910260 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		909912 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RADIL_HUMAN (830-1106): 4.06e-27: 122: 18.06
+	Hs
		683623 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RADIL_HUMAN (830-1106): 4.06e-27: 122: 18.06
+	Mm
		926805 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		683339 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		909498 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		683305 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Mm
		926868 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MYO5A_MOUSE (1409-1824): 1.89e-18: 95: 14.81
+	Mm
		926859 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		LNX2_MOUSE (973-1126): 6.83e-17: 88.9: 20.38