Protein: TR10B
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)

Gene: TR10B, TNFRSF10B
Organism: Homo sapiens
Interactions: 175
UniProt ID: O14763

Gene Ontology (top 5):
GO:0002357 - defense response to tumor cell
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0007166 - cell surface receptor signaling pathway
GO:0007250 - activation of NF-kappaB-inducing kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163260

TNF10
Tumor necrosis factor ligand superfamily member 10

19

20

Small-scale

0.985

High

163292

FADD
FAS-associated death domain protein

13

20

Small-scale

0.977

High

127612

TR10A
Tumor necrosis factor receptor superfamily member 10A

5

16

Small-scale

0.927

High

163251

TNR3
Tumor necrosis factor receptor superfamily member 3

3

16

High-throughput

0.861

High

163308

MICA
MHC class I polypeptide-related sequence A

3

1

High-throughput

0.861

High

163297

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

3

18

Small-scale

0.827

High

71373

HECA2
HEPACAM family member 2

3

4

High-throughput

0.770

High

163302

CASP8
Caspase-8

17

16

Small-scale

0.762

High

163209

CFLAR
CASP8 and FADD-like apoptosis regulator

5

16

Small-scale

0.702

High

163203

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

16

High-throughput

0.691

High

163307

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.691

High

163371

FLVC1
Choline/ethanolamine transporter FLVCR1

4

2

High-throughput

0.691

High

163207

SCAM1
Secretory carrier-associated membrane protein 1

3

4

High-throughput

0.667

High

163210

TSN3
Tetraspanin-3

3

2

High-throughput

0.667

High

163227

FGFR1
Fibroblast growth factor receptor 1

3

19

High-throughput

0.667

High

163231

INGR1
Interferon gamma receptor 1

3

4

High-throughput

0.667

High

163264

MFAP3
Microfibril-associated glycoprotein 3

3

2

High-throughput

0.667

High

163305

VAMP3
Vesicle-associated membrane protein 3

3

4

High-throughput

0.667

High

163316

TM214
Transmembrane protein 214

3

3

High-throughput

0.667

High

163322

LAP4B
Lysosomal-associated transmembrane protein 4B

3

2

High-throughput

0.667

High

163326

S15A4
Solute carrier family 15 member 4

3

1

High-throughput

0.667

High

163351

NFIP1
NEDD4 family-interacting protein 1

3

3

High-throughput

0.667

High

163282

CD83
CD83 antigen

1

0

High-throughput

0.656

High

163290

TRAF2
TNF receptor-associated factor 2

3

20

Small-scale

0.640

High

163370

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

3

0

High-throughput

0.638

High

163204

TR13B
Tumor necrosis factor receptor superfamily member 13B

3

0

High-throughput

0.634

High

163223

FYN
Tyrosine-protein kinase Fyn

2

11

High-throughput

0.628

High

163229

IL1R1
Interleukin-1 receptor type 1

2

6

High-throughput

0.628

High

163255

EAA3
Excitatory amino acid transporter 3

2

3

High-throughput

0.628

High

163288

DDR1
Epithelial discoidin domain-containing receptor 1

2

18

High-throughput

0.628

High

163334

S20A1
Sodium-dependent phosphate transporter 1

2

1

High-throughput

0.628

High

163342

ARRD3
Arrestin domain-containing protein 3

2

3

High-throughput

0.628

High

163248

BASI
Basigin

1

6

High-throughput

0.618

High

163256

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.618

High

163303

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

10

Small-scale

0.618

High

163287

CKAP4
Cytoskeleton-associated protein 4

2

5

High-throughput

0.611

High

163294

STX3
Syntaxin-3

2

4

High-throughput

0.611

High

163327

RN149
E3 ubiquitin-protein ligase RNF149

3

3

High-throughput

0.609

High

163234

MUC1
Mucin-1

2

3

High-throughput

0.606

High

163289

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

2

High-throughput

0.606

High

163276

ASIC1
Acid-sensing ion channel 1

2

0

High-throughput

0.602

High

163268

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.595

High

163343

HAVR1
Hepatitis A virus cellular receptor 1

1

0

Small-scale

0.586

High

163216

EGFR
Epidermal growth factor receptor

2

11

High-throughput

0.584

High

163240

CBL
E3 ubiquitin-protein ligase CBL

2

9

Small-scale

0.584

High

163273

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.584

High

163300

CUL3
Cullin-3

2

9

Small-scale

0.584

High

163368

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.578

High

163225

PGFRB
Platelet-derived growth factor receptor beta

1

13

High-throughput

0.575

High

163238

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

17

Small-scale

0.575

High

163242

TNR6
Tumor necrosis factor receptor superfamily member 6

1

16

Small-scale

0.575

High

163259

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

20

Small-scale

0.575

High

163346

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

3

High-throughput

0.574

High

163369

RNF11
RING finger protein 11

2

4

High-throughput

0.574

High

163270

RHOA
Transforming protein RhoA

2

20

Small-scale

0.571

High

163339

CASPA
Caspase-10

2

16

Small-scale

0.571

High

163306

CEGT
Ceramide glucosyltransferase

2

2

High-throughput

0.558

High

163348

ZDH15
Palmitoyltransferase ZDHHC15

2

3

High-throughput

0.553

High

163280

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

8

Small-scale

0.553

High

163205

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.536

High

163213

VAMP5
Vesicle-associated membrane protein 5

1

4

High-throughput

0.536

High

163237

INAR1
Interferon alpha/beta receptor 1

1

8

High-throughput

0.536

High

163241

PRPH2
Peripherin-2

1

2

High-throughput

0.536

High

163245

V2R
Vasopressin V2 receptor

1

3

High-throughput

0.536

High

163246

RYK
Tyrosine-protein kinase RYK

1

17

High-throughput

0.536

High

163252

TGFR2
TGF-beta receptor type-2

1

11

High-throughput

0.536

High

163253

OPRX
Nociceptin receptor

1

3

High-throughput

0.536

High

163258

GPR3
G-protein coupled receptor 3

1

6

High-throughput

0.536

High

163261

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.536

High

163269

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

163277

KC1G2
Casein kinase I isoform gamma-2

1

11

High-throughput

0.536

High

163286

ACVR1
Activin receptor type-1

1

11

High-throughput

0.536

High

163295

SLAF1
Signaling lymphocytic activation molecule

1

10

High-throughput

0.536

High

163301

AVR2B
Activin receptor type-2B

1

11

High-throughput

0.536

High

163317

I20RB
Interleukin-20 receptor subunit beta

1

4

High-throughput

0.536

High

163328

PLPR1
Phospholipid phosphatase-related protein type 1

1

1

High-throughput

0.536

High

163329

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

6

High-throughput

0.536

High

163331

PKR1
Prokineticin receptor 1

1

2

High-throughput

0.536

High

163338

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.536

High

163340

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

9

High-throughput

0.536

High

163341

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

4

High-throughput

0.536

High

163350

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

6

High-throughput

0.536

High

163352

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

163354

PCDC1
Protocadherin alpha-C1

1

1

High-throughput

0.536

High

163359

GPR35
G-protein coupled receptor 35

1

4

High-throughput

0.536

High

163363

GPC5D
G-protein coupled receptor family C group 5 member D

1

4

High-throughput

0.536

High

163364

GPC5B
G-protein coupled receptor family C group 5 member B

1

4

High-throughput

0.536

High

163365

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

6

High-throughput

0.536

High

163367

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

18

High-throughput

0.536

High

163313

MARH8
E3 ubiquitin-protein ligase MARCHF8

2

6

Small-scale

0.533

High

163220

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.515

High

163263

GDIR1
Rho GDP-dissociation inhibitor 1

1

3

Small-scale

0.514

High

163315

AR26L
Putative ankyrin repeat domain-containing protein 26-like protein

1

6

High-throughput

0.514

High

163214

CSPG5
Chondroitin sulfate proteoglycan 5

1

0

High-throughput

0.513

High

163314

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.513

High

163330

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

163353

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

163362

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.513

High

163372

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

163311

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

5

High-throughput

0.489

High

163217

RASK
GTPase KRas

1

5

High-throughput

0.479

High

163218

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.479

High

163221

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

13

High-throughput

0.479

High

163222

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

163224

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

163228

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

163230

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

163236

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

163239

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

7

Small-scale

0.479

High

163250

BMR1A
Bone morphogenetic protein receptor type-1A

1

11

High-throughput

0.479

High

163254

BCL6
B-cell lymphoma 6 protein

1

8

Small-scale

0.479

High

163262

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

163267

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

163271

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

163279

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

163283

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

163293

CBLB
E3 ubiquitin-protein ligase CBL-B

1

9

Small-scale

0.479

High

163298

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

163299

CUL1
Cullin-1

1

9

Small-scale

0.479

High

163304

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

163319

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

163345

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

7

Small-scale

0.479

High

163347

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

163349

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

2

Small-scale

0.479

High

163355

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.479

High

163356

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

163358

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

163226

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

163272

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

163296

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

163324

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.458

High

163337

CLC4D
C-type lectin domain family 4 member D

1

0

High-throughput

0.458

High

163344

RN183
E3 ubiquitin-protein ligase RNF183

1

0

Small-scale

0.458

High

163215

TSN12
Tetraspanin-12

1

2

Small-scale

0.445

High

163219

B3AT
Band 3 anion transport protein

1

3

High-throughput

0.445

High

163232

EZRI
Ezrin

1

7

Small-scale

0.445

High

163243

MOES
Moesin

1

7

Small-scale

0.445

High

163249

MOT8
Monocarboxylate transporter 8

1

3

High-throughput

0.445

High

163257

MK08
Mitogen-activated protein kinase 8

1

7

Small-scale

0.445

High

163265

BID
BH3-interacting domain death agonist

1

2

Small-scale

0.445

High

163284

LAT1
Large neutral amino acids transporter small subunit 1

1

5

High-throughput

0.445

High

163285

SC6A3
Sodium-dependent dopamine transporter

1

3

High-throughput

0.445

High

163291

PAK1
Serine/threonine-protein kinase PAK 1

1

3

Small-scale

0.445

High

163309

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.445

High

163333

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.445

High

163336

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

163360

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

163310

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

Small-scale

0.439

High

163206

TRI66
Tripartite motif-containing protein 66

1

4

High-throughput

0.437

High

163208

BET1
BET1 homolog

1

1

High-throughput

0.437

High

163211

PRAF2
PRA1 family protein 2

1

2

High-throughput

0.437

High

163212

PRDM1
PR domain zinc finger protein 1

1

7

Small-scale

0.437

High

163235

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.437

High

163247

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

163274

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.437

High

163275

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

163281

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

163318

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

163321

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

6

High-throughput

0.437

High

163325

STX12
Syntaxin-12

1

3

High-throughput

0.437

High

163332

RN128
E3 ubiquitin-protein ligase RNF128

1

3

High-throughput

0.437

High

163366

DNJ5B
DnaJ homolog subfamily C member 5B

1

7

High-throughput

0.437

High

65404

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.426

High

163320

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

163266

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

1

High-throughput

0.407

High

163278

DLK1
Protein delta homolog 1

1

1

High-throughput

0.407

High

163357

TM231
Transmembrane protein 231

3

0

High-throughput

0.347

High

163361

GINM1
Glycoprotein integral membrane protein 1

3

0

High-throughput

0.347

High

49417

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

156542

C56D2
Transmembrane reductase CYB561D2

1

0

High-throughput

0.279

Low

163335

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

0

High-throughput

0.279

Low

163312

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

163233

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

163244

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

163323

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025