HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	26496610, 35271311, 33961781, 24255178, 17979178, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~14-3-3
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0019899 - enzyme binding GO:0019904 - protein domain specific binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 246
+	At
		788518 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14333_ARATH (1-244): 1.01e-141: 398: 61.38
+	Hs
		909424 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	At
		965289 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14332_ARATH (4-244): 8.72e-141: 396: 60.91
+	At
		788342 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14331_ARATH (4-244): 2.19e-140: 395: 59.67
+	At
		788392 14337_ARATH (1-239): 1.25e-144: 406: 61.73		14331_ARATH (4-244): 2.19e-140: 395: 59.67
+	At
		802000 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14334_ARATH (4-244): 5.36e-139: 392: 60.49
+	At
		965322 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14339_ARATH (2-246): 8.32e-139: 391: 57.96
+	Hs
		904421 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Mm
		905329 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433G_MOUSE (1-246): 9.38e-138: 388: 86.99
+	Sl
		955649 14336_SOLLC (1-241): 8.27e-144: 404: 63.82		14337_SOLLC (2-241): 3.63e-138: 389: 58.75
+	Hs
		909467 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Mm
		910226 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433F_MOUSE (1-246): 6.15e-136: 383: 99.19
+	Mm
		910224 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433Z_MOUSE (3-245): 5.23e-108: 313: 74.49
+	Dm
		664602 1433E_DROME (3-245): 4.63e-144: 405: 64.90		1433Z_DROME (3-242): 8.23e-108: 312: 73.33
+	Hs
		909429 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683249 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Mm
		910331 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433B_MOUSE (3-245): 9.94e-107: 310: 75.92
+	Hs
		646775 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		646664 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		683936 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20