Protein: CD27
CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)

Gene: CD27
Organism: Homo sapiens
Interactions: 108
UniProt ID: P26842

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0009897 - external side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689804

CD70
CD70 antigen

4

1

Small-scale

0.895

High

689820

TRAF2
TNF receptor-associated factor 2

6

20

Small-scale

0.733

High

689807

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

4

High-throughput

0.691

High

65335

TCAF2
TRPM8 channel-associated factor 2

4

2

High-throughput

0.691

High

178718

SCAM1
Secretory carrier-associated membrane protein 1

3

4

High-throughput

0.667

High

250054

ADCY9
Adenylate cyclase type 9

3

1

High-throughput

0.667

High

255984

S19A2
Thiamine transporter 1

3

2

High-throughput

0.667

High

407837

SEMG1
Semenogelin-1

3

1

High-throughput

0.667

High

689824

BIRC2
Baculoviral IAP repeat-containing protein 2

3

12

High-throughput

0.667

High

689827

AT2B3
Plasma membrane calcium-transporting ATPase 3

3

9

High-throughput

0.667

High

689843

COQ8B
Atypical kinase COQ8B, mitochondrial

3

1

High-throughput

0.667

High

689854

TTYH3
Protein tweety homolog 3

3

1

High-throughput

0.667

High

689857

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

4

7

High-throughput

0.630

High

689863

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

4

1

High-throughput

0.630

High

186243

SIVA
Apoptosis regulatory protein Siva

2

0

Small-scale

0.613

High

374413

RASH
GTPase HRas

2

3

High-throughput

0.611

High

689816

SEMG2
Semenogelin-2

3

1

High-throughput

0.609

High

689837

GOGA5
Golgin subfamily A member 5

3

5

High-throughput

0.609

High

689850

CIB1
Calcium and integrin-binding protein 1

2

2

High-throughput

0.606

High

689803

CTR1
High affinity cationic amino acid transporter 1

2

5

High-throughput

0.601

High

569162

CD59
CD59 glycoprotein

2

0

High-throughput

0.585

High

689815

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

0

High-throughput

0.585

High

689822

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.584

High

689835

F241A
Uncharacterized protein FAM241A

2

1

High-throughput

0.558

High

689844

SAAL1
Protein SAAL1

2

1

High-throughput

0.558

High

689847

CREL1
Protein disulfide isomerase CRELD1

2

1

High-throughput

0.558

High

165532

SCAM3
Secretory carrier-associated membrane protein 3

2

4

High-throughput

0.549

High

689806

ACTN2
Alpha-actinin-2

1

0

High-throughput

0.549

High

443666

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.536

High

627262

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

11

High-throughput

0.536

High

689800

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

2

High-throughput

0.536

High

689823

S39A6
Zinc transporter ZIP6

1

10

High-throughput

0.536

High

689840

S38A5
Sodium-coupled neutral amino acid transporter 5

1

3

High-throughput

0.536

High

689849

SORT
Sortilin

1

6

High-throughput

0.536

High

689858

S38A1
Sodium-coupled neutral amino acid symporter 1

1

3

High-throughput

0.536

High

689867

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

2

High-throughput

0.536

High

689870

AGRE2
Adhesion G protein-coupled receptor E2

1

1

High-throughput

0.536

High

689875

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.536

High

689834

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

184384

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

689802

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

689814

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

689855

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

689848

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.512

High

689819

KDSR
3-ketodihydrosphingosine reductase

1

2

High-throughput

0.489

High

689830

ODR4
Protein odr-4 homolog

1

1

High-throughput

0.489

High

689831

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

2

High-throughput

0.489

High

689836

ZNT7
Zinc transporter 7

1

4

High-throughput

0.489

High

689838

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.489

High

689841

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

10

High-throughput

0.489

High

689842

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.489

High

689859

GHITM
Growth hormone-inducible transmembrane protein

1

1

High-throughput

0.489

High

689860

AT131
Endoplasmic reticulum transmembrane helix translocase

1

13

High-throughput

0.489

High

689864

UFSP2
Ufm1-specific protease 2

1

1

High-throughput

0.489

High

689868

ZDHC3
Palmitoyltransferase ZDHHC3

1

2

High-throughput

0.489

High

136663

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

689872

EPCR
Endothelial protein C receptor

1

0

High-throughput

0.458

High

689812

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.445

High

689839

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.445

High

689865

CYRIB
CYFIP-related Rac1 interactor B

1

1

High-throughput

0.445

High

689821

TRAF1
TNF receptor-associated factor 1

1

20

Small-scale

0.437

High

689832

TM214
Transmembrane protein 214

1

3

High-throughput

0.437

High

479113

ENOG
Gamma-enolase

1

0

High-throughput

0.426

High

689813

IST1
IST1 homolog

1

0

High-throughput

0.426

High

689825

TTL12
Tubulin--tyrosine ligase-like protein 12

1

0

High-throughput

0.426

High

689846

PGM2
Phosphopentomutase

1

0

High-throughput

0.426

High

689851

CPNE1
Copine-1

1

0

High-throughput

0.426

High

689853

NEUL
Neurolysin, mitochondrial

1

0

High-throughput

0.426

High

689876

HEBP2
Heme-binding protein 2

1

0

High-throughput

0.426

High

162786

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

5

High-throughput

0.407

High

176649

PUR4
Phosphoribosylformylglycinamidine synthase

1

1

High-throughput

0.407

High

211478

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

1

High-throughput

0.407

High

226707

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

10

High-throughput

0.407

High

227060

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

300111

GLRX3
Glutaredoxin-3

1

3

High-throughput

0.407

High

333856

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

1

High-throughput

0.407

High

357913

CYB5
Cytochrome b5

1

3

High-throughput

0.407

High

689801

ECHM
Enoyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.407

High

689808

SYAC
Alanine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

689810

GUAA
GMP synthase [glutamine-hydrolyzing]

1

2

High-throughput

0.407

High

689817

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

8

High-throughput

0.407

High

689818

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

8

High-throughput

0.407

High

689845

C1GLC
C1GALT1-specific chaperone 1

1

1

High-throughput

0.407

High

689852

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

1

High-throughput

0.407

High

689861

XPP1
Xaa-Pro aminopeptidase 1

1

1

High-throughput

0.407

High

689869

OGFR
Opioid growth factor receptor

1

3

High-throughput

0.407

High

689829

MKS3
Meckelin

3

0

High-throughput

0.347

High

684473

CTNA2
Catenin alpha-2

2

0

High-throughput

0.318

High

269991

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.279

Low

299613

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.279

Low

397782

ATP8
ATP synthase F(0) complex subunit 8

1

0

High-throughput

0.279

Low

665519

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.279

Low

689833

TM205
Transmembrane protein 205

1

0

High-throughput

0.279

Low

689856

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

689871

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

689873

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.279

Low

689828

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

135505

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.232

Low

321079

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.232

Low

599504

FAAA
Fumarylacetoacetase

1

0

High-throughput

0.232

Low

663347

KTHY
Thymidylate kinase

1

0

High-throughput

0.232

Low

689805

SPRE
Sepiapterin reductase

1

0

High-throughput

0.232

Low

689809

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

0

High-throughput

0.232

Low

689811

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

0

High-throughput

0.232

Low

689826

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.232

Low

689862

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.232

Low

689866

PNPO
Pyridoxine-5'-phosphate oxidase

1

0

High-throughput

0.232

Low

689874

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025