HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.816

Property	Details
Experiments	10620507, 21900206
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 592
+	Hs
		926956 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCZ_HUMAN (1-592): 0: 688: 100.00
+	Hs
		783970 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		683182 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		783973 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		683287 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Hs
		926957 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		568616 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		116995 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SGK1_HUMAN (199-583): 7.41e-144: 424: 38.36
+	Hs
		568620 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		116972 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		SGK1_HUMAN (199-583): 7.41e-144: 424: 38.36
+	Hs
		683216 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47
+	Hs
		909458 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		683276 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		926942 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Mm
		554936 1433B_MOUSE (1-246): 5.56e-141: 396: 98.78		KPCE_MOUSE (6-190): 3.27e-27: 118: 18.91
+	Hs
		566348 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		397155 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCG_HUMAN (116-180): 1.87e-10: 65.9: 36.92
+	Hs
		566293 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63