HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: STK3 (Q13188)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Gene: STK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36736316, 24255178
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 491
+	Hs
		909512 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK3_HUMAN (1-491): 1.83e-172: 496: 100.00
+	Hs
		646859 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		STK3_HUMAN (1-491): 1.83e-172: 496: 100.00
+	Hs
		909502 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK4_HUMAN (6-491): 3.63e-151: 441: 75.57
+	Hs
		683308 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK4_HUMAN (6-491): 3.63e-151: 441: 75.57
+	At
		965291 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CDPK1_ARATH (6-456): 1.49e-140: 418: 20.59
+	At
		802001 14334_ARATH (2-241): 1.74e-141: 398: 61.07		CDPK1_ARATH (6-456): 1.49e-140: 418: 20.59
+	Hs
		646852 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		STK4_HUMAN (6-491): 3.63e-151: 441: 75.57
+	Hs
		131551 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK25_HUMAN (9-426): 4.69e-123: 368: 40.28
+	Hs
		131562 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		STK25_HUMAN (9-426): 4.69e-123: 368: 40.28
+	Hs
		904507 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		STK4_HUMAN (6-491): 3.63e-151: 441: 75.57
+	Hs
		926996 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		PAK1_HUMAN (6-302): 2.26e-118: 359: 41.81
+	Hs
		683216 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KS6A3_HUMAN (22-297): 8.86e-98: 312: 28.42
+	Hs
		646741 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KS6A3_HUMAN (22-297): 8.86e-98: 312: 28.42
+	Hs
		927320 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MYO3A_HUMAN (23-278): 7.28e-76: 261: 49.82
+	Hs
		909881 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		M4K1_HUMAN (17-278): 3.39e-72: 246: 44.98
+	Hs
		909810 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MINK1_HUMAN (5-316): 3.34e-70: 244: 43.43
+	Hs
		683539 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MINK1_HUMAN (5-316): 3.34e-70: 244: 43.43
+	Hs
		927301 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MINK1_HUMAN (5-316): 3.34e-70: 244: 43.43
+	Hs
		850630 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		KS6A3_HUMAN (22-297): 8.86e-98: 312: 28.42
+	Hs
		647104 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		MINK1_HUMAN (5-316): 3.34e-70: 244: 43.43