HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: TNK1 (Q13470)
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
Gene: TNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	25852190, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 666
+	Hs
		909526 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		TNK1_HUMAN (1-666): 0: 538: 100.00
+	Hs
		927010 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		TNK1_HUMAN (1-666): 0: 538: 100.00
+	Hs
		337416 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		337366 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383724 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	At
		965327 14332_ARATH (1-241): 4.75e-145: 407: 63.27		PBS1_ARATH (36-471): 3.55e-129: 390: 17.94
+	Hs
		337420 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		383732 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	At
		788521 14333_ARATH (3-241): 4.44e-143: 402: 62.96		PBL9_ARATH (59-404): 2.54e-121: 369: 21.96
+	Hs
		337355 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		ABL1_HUMAN (22-643): 2.23e-124: 397: 21.38
+	Hs
		411661 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	Hs
		383624 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		ERBB2_HUMAN (65-631): 7.95e-122: 393: 22.82
+	Hs
		411666 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		LCK_HUMAN (91-392): 1.46e-113: 352: 30.46
+	Hs
		909589 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ERBB4_HUMAN (89-373): 2.84e-46: 179: 36.68
+	Hs
		338232 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		338008 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		909560 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		FAK2_HUMAN (92-373): 3.64e-45: 175: 36.88
+	Hs
		338257 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		337969 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		EGFR_HUMAN (89-373): 4.38e-46: 178: 36.59
+	Hs
		926964 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ACK1_HUMAN (391-664): 6.16e-22: 103: 20.79