Protein: TNR1B
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]

Gene: TNR1B, TNFRSF1B
Organism: Homo sapiens
Interactions: 234
UniProt ID: P20333

Gene Ontology (top 5):
GO:0002718 - regulation of cytokine production involved in immune response
GO:0002724 - regulation of T cell cytokine production
GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0003176 - aortic valve development
GO:0003177 - pulmonary valve development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

352486

TNFA
Tumor necrosis factor

16

20

Small-scale

0.986

High

352409

TNFB
Lymphotoxin-alpha

3

20

Small-scale

0.858

High

591261

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

16

Small-scale

0.806

High

591317

TRAF2
TNF receptor-associated factor 2

14

20

Small-scale

0.760

High

584311

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

16

Small-scale

0.754

High

591319

TRAF1
TNF receptor-associated factor 1

7

20

Small-scale

0.749

High

255498

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.691

High

591372

FGRL1
Fibroblast growth factor receptor-like 1

1

6

High-throughput

0.691

High

591325

BIRC2
Baculoviral IAP repeat-containing protein 2

3

12

Small-scale

0.656

High

591320

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.624

High

591442

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

16

Small-scale

0.618

High

591278

KC1A
Casein kinase I isoform alpha

2

8

Small-scale

0.602

High

591302

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

2

4

Small-scale

0.595

High

591266

GRN
Progranulin

1

2

Small-scale

0.586

High

505934

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

2

0

High-throughput

0.585

High

591336

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

2

9

Small-scale

0.584

High

201210

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

5

High-throughput

0.536

High

212594

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.536

High

272489

OFD1
Centriole and centriolar satellite protein OFD1

1

7

High-throughput

0.536

High

273546

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.536

High

591269

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

591279

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

591283

KC1E
Casein kinase I isoform epsilon

1

9

High-throughput

0.536

High

591308

SP2
Transcription factor Sp2

1

6

High-throughput

0.536

High

591312

UBXN1
UBX domain-containing protein 1

1

7

High-throughput

0.536

High

591316

TROP
Trophinin

1

10

High-throughput

0.536

High

591318

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.536

High

591333

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.536

High

591348

RRP12
RRP12-like protein

1

1

High-throughput

0.536

High

591355

FIGL1
Fidgetin-like protein 1

1

6

High-throughput

0.536

High

591365

LUZP1
Leucine zipper protein 1

1

6

High-throughput

0.536

High

591368

C2CD5
C2 domain-containing protein 5

1

3

High-throughput

0.536

High

591378

VANG1
Vang-like protein 1

1

3

High-throughput

0.536

High

591395

KIF2C
Kinesin-like protein KIF2C

1

7

High-throughput

0.536

High

591412

SLK
STE20-like serine/threonine-protein kinase

1

2

High-throughput

0.536

High

591419

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

2

High-throughput

0.536

High

591426

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.536

High

591430

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.536

High

591432

VANG2
Vang-like protein 2

1

3

High-throughput

0.536

High

591437

FND3A
Fibronectin type-III domain-containing protein 3A

1

7

High-throughput

0.536

High

591441

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.536

High

591339

PKN1
Serine/threonine-protein kinase N1

1

7

Small-scale

0.528

High

441010

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.518

High

591281

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

591290

DRG2
Developmentally-regulated GTP-binding protein 2

1

0

High-throughput

0.513

High

591293

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

591304

VIGLN
Vigilin

1

0

High-throughput

0.513

High

591341

TPD53
Tumor protein D53

1

0

High-throughput

0.513

High

591363

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.513

High

591385

NKD2
Protein naked cuticle homolog 2

1

0

High-throughput

0.513

High

591390

PRR11
Proline-rich protein 11

1

0

High-throughput

0.513

High

591398

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

591401

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.513

High

591403

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

591428

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

316302

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

2

Small-scale

0.504

High

301610

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

Small-scale

0.501

High

408731

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.501

High

591379

ZN420
Zinc finger protein 420

1

1

High-throughput

0.494

High

591374

KC1AL
Casein kinase I isoform alpha-like

1

11

Small-scale

0.489

High

275623

POP7
Ribonuclease P protein subunit p20

1

1

High-throughput

0.489

High

315968

CBX6
Chromobox protein homolog 6

1

3

High-throughput

0.489

High

591289

TTC3
E3 ubiquitin-protein ligase TTC3

1

12

High-throughput

0.489

High

591311

ZNF92
Zinc finger protein 92

1

4

High-throughput

0.489

High

591321

STX5
Syntaxin-5

1

4

High-throughput

0.489

High

591323

ORC1
Origin recognition complex subunit 1

1

6

High-throughput

0.489

High

591329

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.489

High

591330

CBX2
Chromobox protein homolog 2

1

3

High-throughput

0.489

High

591334

OZF
Zinc finger protein OZF

1

2

High-throughput

0.489

High

591335

TTF1
Transcription termination factor 1

1

1

High-throughput

0.489

High

591349

ZMYM1
Zinc finger MYM-type protein 1

1

2

High-throughput

0.489

High

591351

ZN770
Zinc finger protein 770

1

3

High-throughput

0.489

High

591354

NFRKB
Nuclear factor related to kappa-B-binding protein

1

3

High-throughput

0.489

High

591356

SAMD1
Sterile alpha motif domain-containing protein 1

1

4

High-throughput

0.489

High

591357

SAS6
Spindle assembly abnormal protein 6 homolog

1

10

High-throughput

0.489

High

591358

AEBP2
Zinc finger protein AEBP2

1

7

High-throughput

0.489

High

591361

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.489

High

591366

CEP57
Centrosomal protein of 57 kDa

1

1

High-throughput

0.489

High

591367

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

4

High-throughput

0.489

High

591370

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.489

High

591371

ZN101
Zinc finger protein 101

1

8

High-throughput

0.489

High

591376

Z280C
Zinc finger protein 280C

1

8

High-throughput

0.489

High

591377

CC112
Coiled-coil domain-containing protein 112

1

2

High-throughput

0.489

High

591391

LLR1
Leucine-rich repeat protein 1

1

1

High-throughput

0.489

High

591392

ZN512
Zinc finger protein 512

1

3

High-throughput

0.489

High

591393

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

3

High-throughput

0.489

High

591396

CDC6
Cell division control protein 6 homolog

1

7

High-throughput

0.489

High

591400

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

591409

SP130
Histone deacetylase complex subunit SAP130

1

3

High-throughput

0.489

High

591413

ZN696
Zinc finger protein 696

1

5

High-throughput

0.489

High

591414

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.489

High

591420

SPS2L
SPATS2-like protein

1

4

High-throughput

0.489

High

591423

FAIM1
Fas apoptotic inhibitory molecule 1

1

1

High-throughput

0.489

High

591440

TNPO3
Transportin-3

1

18

High-throughput

0.489

High

591439

ASB3
Ankyrin repeat and SOCS box protein 3

1

4

Small-scale

0.488

High

591435

UBQL1
Ubiquilin-1

1

9

High-throughput

0.481

High

2074

A0A0B4J269
Tubulin beta-3 chain

1

15

High-throughput

0.479

High

153276

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

1

High-throughput

0.479

High

162401

XPO1
Exportin-1

1

16

High-throughput

0.479

High

163746

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

11

High-throughput

0.479

High

167470

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

18

Small-scale

0.479

High

312180

IPO7
Importin-7

1

13

High-throughput

0.479

High

323584

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.479

High

325032

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

381122

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.479

High

381795

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

393030

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

11

High-throughput

0.479

High

397265

ADT2
ADP/ATP translocase 2

1

5

High-throughput

0.479

High

409003

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.479

High

428016

TBB5
Tubulin beta chain

1

15

High-throughput

0.479

High

432546

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.479

High

443324

VIME
Vimentin

1

4

High-throughput

0.479

High

474918

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

11

High-throughput

0.479

High

501669

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.479

High

503419

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

518084

ADT1
ADP/ATP translocase 1

1

5

High-throughput

0.479

High

518246

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.479

High

561497

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

10

High-throughput

0.479

High

564001

HSP76
Heat shock 70 kDa protein 6

1

7

High-throughput

0.479

High

573128

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

591262

FLNA
Filamin-A

1

2

High-throughput

0.479

High

591263

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

591264

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

591265

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.479

High

591267

SPB3
Serpin B3

1

1

High-throughput

0.479

High

591268

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.479

High

591270

HS71L
Heat shock 70 kDa protein 1-like

1

7

High-throughput

0.479

High

591271

MYH9
Myosin-9

1

4

High-throughput

0.479

High

591273

GRP75
Stress-70 protein, mitochondrial

1

16

High-throughput

0.479

High

591274

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

591275

BCL6
B-cell lymphoma 6 protein

1

6

Small-scale

0.479

High

591277

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.479

High

591280

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

591286

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

12

Small-scale

0.479

High

591288

COPB
Coatomer subunit beta

1

1

High-throughput

0.479

High

591291

XPO2
Exportin-2

1

10

High-throughput

0.479

High

591292

EPIPL
Epiplakin

1

3

High-throughput

0.479

High

591294

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.479

High

591295

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.479

High

591298

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

591300

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.479

High

591301

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.479

High

591303

S25A3
Solute carrier family 25 member 3

1

7

High-throughput

0.479

High

591305

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.479

High

591306

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.479

High

591307

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

High-throughput

0.479

High

591309

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

8

High-throughput

0.479

High

591310

CAV1
Caveolin-1

1

5

Small-scale

0.479

High

591314

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

591324

BIRC3
Baculoviral IAP repeat-containing protein 3

1

11

Small-scale

0.479

High

591326

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

18

Small-scale

0.479

High

591331

IMB1
Importin subunit beta-1

1

7

High-throughput

0.479

High

591338

AAAT
Neutral amino acid transporter B(0)

1

3

High-throughput

0.479

High

591383

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

7

High-throughput

0.479

High

591384

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.479

High

591388

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

Small-scale

0.479

High

591397

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

Small-scale

0.479

High

591404

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

7

Small-scale

0.479

High

591407

ACTBM
Putative beta-actin-like protein 3

1

3

High-throughput

0.479

High

591415

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

9

Small-scale

0.479

High

591421

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.479

High

591434

MYO6
Unconventional myosin-VI

1

7

High-throughput

0.479

High

591436

Q9UQC1
Heat shock protein 72

1

9

High-throughput

0.479

High

591438

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

591405

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.470

High

151709

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

538097

ENPL
Endoplasmin

1

0

High-throughput

0.458

High

591296

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

591297

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

591322

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.458

High

591386

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

118194

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

178108

IPO8
Importin-8

1

12

High-throughput

0.437

High

207888

XPOT
Exportin-T

1

13

High-throughput

0.437

High

591272

MYH10
Myosin-10

1

4

High-throughput

0.437

High

591276

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.437

High

591285

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.437

High

591287

TXTP
Tricarboxylate transport protein, mitochondrial

1

7

High-throughput

0.437

High

591313

EF1A2
Elongation factor 1-alpha 2

1

4

High-throughput

0.437

High

591328

RCN2
Reticulocalbin-2

1

4

High-throughput

0.437

High

591332

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.437

High

591337

PCH2
Pachytene checkpoint protein 2 homolog

1

5

High-throughput

0.437

High

591340

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.437

High

591344

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.437

High

591359

RS27L
Ribosomal protein eS27-like

1

2

High-throughput

0.437

High

591362

MON2
Protein MON2 homolog

1

8

High-throughput

0.437

High

591369

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.437

High

591387

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

High-throughput

0.437

High

591389

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.437

High

591402

TBB2B
Tubulin beta-2B chain

1

15

High-throughput

0.437

High

591406

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

Small-scale

0.437

High

591411

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

3

High-throughput

0.437

High

591416

XPO5
Exportin-5

1

13

High-throughput

0.437

High

591422

ATD3A
ATPase family AAA domain-containing protein 3A

1

5

High-throughput

0.437

High

591429

HACD3
Very-long-chain

1

1

High-throughput

0.437

High

591418

XPP3
Xaa-Pro aminopeptidase 3

2

0

High-throughput

0.318

High

236694

CCNT1
Cyclin-T1

1

0

High-throughput

0.279

Low

256461

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.279

Low

302888

HEXI1
Protein HEXIM1

1

0

High-throughput

0.279

Low

508820

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.279

Low

534058

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

570620

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.279

Low

591282

PRI2
DNA primase large subunit

1

0

High-throughput

0.279

Low

591284

DNLI3
DNA ligase 3

1

0

High-throughput

0.279

Low

591315

DYH14
Dynein axonemal heavy chain 14

1

0

High-throughput

0.279

Low

591327

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.279

Low

591342

GEN
Flap endonuclease GEN homolog 1

1

0

High-throughput

0.279

Low

591343

MOONR
Protein moonraker

1

0

High-throughput

0.279

Low

591345

BOREA
Borealin

1

0

High-throughput

0.279

Low

591346

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

591347

FA76B
Protein FAM76B

1

0

High-throughput

0.279

Low

591352

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.279

Low

591353

ARMX5
Armadillo repeat-containing X-linked protein 5

1

0

High-throughput

0.279

Low

591360

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.279

Low

591364

CENPV
Centromere protein V

1

0

High-throughput

0.279

Low

591373

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.279

Low

591375

POC5
Centrosomal protein POC5

1

0

High-throughput

0.279

Low

591380

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.279

Low

591381

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.279

Low

591382

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

591394

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.279

Low

591399

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

High-throughput

0.279

Low

591408

IN80B
INO80 complex subunit B

1

0

High-throughput

0.279

Low

591410

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.279

Low

591417

AKIP1
A-kinase-interacting protein 1

1

0

High-throughput

0.279

Low

591424

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.279

Low

591425

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.279

Low

591427

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.279

Low

591431

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.279

Low

591433

APC10
Anaphase-promoting complex subunit 10

1

0

High-throughput

0.279

Low

197225

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.249

Low

591299

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.249

Low

591350

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024