HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: RGRF1 (Q13972)
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)
Gene: RASGRF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9543386
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1273
+	Mm
		926773 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		RGRF2_MOUSE (1-1272): 0: 926: 64.37
+	Hs
		910200 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RPGF2_HUMAN (513-1253): 7.73e-98: 345: 16.13
+	Hs
		683851 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RPGF2_HUMAN (513-1253): 7.73e-98: 345: 16.13
+	Mm
		926845 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		RPGF2_MOUSE (513-1273): 3.59e-99: 349: 16.09
+	Hs
		909851 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RPGF6_HUMAN (513-1269): 4.92e-96: 341: 14.45
+	Hs
		683569 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RPGF6_HUMAN (513-1269): 4.92e-96: 341: 14.45
+	Hs
		927702 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RPGF2_HUMAN (513-1253): 7.73e-98: 345: 16.13
+	Hs
		927336 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RPGF6_HUMAN (513-1269): 4.92e-96: 341: 14.45
+	Hs
		909717 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		FGD6_HUMAN (94-623): 5.12e-93: 330: 18.15
+	Hs
		683475 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		FGD6_HUMAN (94-623): 5.12e-93: 330: 18.15
+	Hs
		927201 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		FGD6_HUMAN (94-623): 5.12e-93: 330: 18.15
+	Hs
		171544 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RGL2_HUMAN (833-1273): 1.04e-92: 318: 19.34
+	Hs
		171538 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RGL2_HUMAN (833-1273): 1.04e-92: 318: 19.34
+	Hs
		909921 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SPT13_HUMAN (125-649): 9.22e-92: 312: 14.96
+	Hs
		683631 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SPT13_HUMAN (125-649): 9.22e-92: 312: 14.96
+	Hs
		927416 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SPT13_HUMAN (125-649): 9.22e-92: 312: 14.96
+	Hs
		171537 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		RGL2_HUMAN (833-1273): 1.04e-92: 318: 19.34
+	Hs
		909770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RGPS2_HUMAN (1037-1273): 3.31e-76: 266: 31.97
+	Hs
		683515 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RGPS2_HUMAN (1037-1273): 3.31e-76: 266: 31.97
+	Hs
		927257 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RGPS2_HUMAN (1037-1273): 3.31e-76: 266: 31.97