HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 577
+	Hs
		502823 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64
+	Hs
		909555 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		683340 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Mm
		93548 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DESP_MOUSE (8-574): 5.01e-15: 81: 9.86
+	Hs
		909975 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		551660 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		909625 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		683394 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		725130 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		522602 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MYH7_HUMAN (171-563): 8.39e-15: 80.3: 16.29
+	Mm
		910250 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		GRDN_MOUSE (94-573): 1.71e-11: 69.5: 9.84
+	Mm
		926804 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MYH10_MOUSE (233-561): 5.58e-13: 74.5: 11.18
+	Hs
		728460 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Hs
		909488 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CGNL1_HUMAN (196-556): 1.23e-10: 66.8: 12.06
+	Hs
		683298 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CGNL1_HUMAN (196-556): 1.23e-10: 66.8: 12.06
+	Mm
		926795 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		GRDN_MOUSE (94-573): 1.71e-11: 69.5: 9.84
+	Mm
		926886 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MY18A_MOUSE (149-549): 2.32e-11: 69.3: 15.44
+	Hs
		728466 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Mm
		926855 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MYH9_MOUSE (266-576): 6.92e-10: 64.5: 13.51
+	Hs
		724761 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08