HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15324660, 17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1358
+	Hs
		909952 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PI3R4_HUMAN (1-1358): 0: 1154: 100.00
+	Hs
		910013 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK2_HUMAN (10-996): 3.01e-151: 483: 12.43
+	Hs
		683699 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SIK2_HUMAN (10-996): 3.01e-151: 483: 12.43
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		788672 14333_ARATH (3-241): 4.44e-143: 402: 62.96		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	Mm
		659446 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2B_MOUSE (24-470): 6.44e-103: 340: 15.13
+	Hs
		909532 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Mm
		926819 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2D_MOUSE (24-470): 8.31e-101: 332: 14.91
+	Hs
		910174 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Hs
		683826 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Mm
		515221 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2A_MOUSE (24-470): 3.62e-98: 324: 15.35
+	At
		965300 14332_ARATH (1-241): 4.75e-145: 407: 63.27		PRL2_ARATH (811-1289): 1.52e-83: 284: 15.46
+	Mm
		910266 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NUAK1_MOUSE (2-311): 1.93e-75: 266: 21.56
+	Hs
		229938 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		229927 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		910009 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91
+	Hs
		883214 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	Hs
		683233 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	At
		788540 14333_ARATH (3-241): 4.44e-143: 402: 62.96		PRL1_ARATH (761-1189): 1.23e-13: 77.2: 12.47