HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	27591049, 35271311, 36931259, 24255178
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 956
+	Hs
		910060 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		927563 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		647304 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		905148 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		982530 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		684342 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		CYLD_HUMAN (1-956): 0: 1872: 100.00