HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: AAPK2 (P54646)
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Gene: PRKAA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36736316, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 552
+	Hs
		871354 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK2_HUMAN (1-552): 0: 570: 100.00
+	Hs
		684009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK1_HUMAN (2-552): 0: 535: 74.86
+	Hs
		909507 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK1_HUMAN (2-552): 0: 535: 74.86
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (2-552): 0: 530: 74.68
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (6-545): 9.52e-149: 448: 29.22
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (2-536): 3.21e-143: 434: 30.07
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (8-552): 5.72e-142: 429: 27.52
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (6-545): 9.52e-149: 448: 29.22
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (1-400): 3.94e-134: 414: 37.69
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (6-545): 9.91e-146: 440: 29.40
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (1-451): 1.42e-147: 435: 27.97
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (2-536): 3.21e-143: 434: 30.07
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (7-536): 2.33e-142: 430: 28.63
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (8-552): 5.72e-142: 429: 27.52
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (7-536): 9.32e-142: 429: 28.63
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (8-552): 5.84e-141: 427: 27.52
+	Hs
		684192 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		BRSK2_HUMAN (13-268): 1.45e-80: 268: 50.00
+	Hs
		909786 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		BRSK2_HUMAN (13-268): 1.45e-80: 268: 50.00
+	Mm
		910248 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK1_MOUSE (13-268): 3.43e-80: 268: 50.39
+	Mm
		910272 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRSK2_MOUSE (13-268): 1.35e-80: 268: 50.00