Protein: THIO2
Thioredoxin-2 (DmTrx-2)

Gene: THIO2, Trx2
Organism: Drosophila melanogaster
Interactions: 210
UniProt ID: Q9V429

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006979 - response to oxidative stress
GO:0008340 - determination of adult lifespan
GO:0015035 - protein-disulfide reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1019628

TRXR1
Thioredoxin reductase 1, mitochondrial

2

9

High-throughput

0.737

High

1262835

Q7JX87
1-Cys peroxiredoxin

2

20

High-throughput

0.737

High

1465092

Q9W022
GEO01508p1

2

16

High-throughput

0.737

High

929527

PDI
Protein disulfide-isomerase

2

18

High-throughput

0.659

High

1465061

TRXR2
Thioredoxin reductase 2, mitochondrial

1

9

High-throughput

0.618

High

1266436

NO66
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

2

2

High-throughput

0.594

High

54045

A1Z892
1-Cys peroxiredoxin

1

20

High-throughput

0.575

High

968553

CALM
Calmodulin

1

1

High-throughput

0.575

High

1464120

Q9V3Q4
thioredoxin-dependent peroxiredoxin

1

20

High-throughput

0.575

High

1465013

PDIA6
Protein disulfide-isomerase A6 homolog

1

18

High-throughput

0.575

High

1465093

Q9W0H8
Reticulocalbin-3

1

11

High-throughput

0.575

High

195081

O16043
Anon1A4

2

1

High-throughput

0.571

High

356393

O97102
Small ubiquitin-related modifier

2

3

High-throughput

0.571

High

578116

ENO
Enolase

2

4

High-throughput

0.571

High

609433

PCNA
Proliferating cell nuclear antigen

2

2

High-throughput

0.571

High

649080

ANX10
Annexin B10

2

5

High-throughput

0.571

High

668123

PPIA
Peptidyl-prolyl cis-trans isomerase

2

10

High-throughput

0.571

High

871653

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

2

11

High-throughput

0.571

High

963867

SODC
Superoxide dismutase [Cu-Zn]

2

7

High-throughput

0.571

High

1176564

NLP
Nucleoplasmin-like protein

2

6

High-throughput

0.571

High

1306109

Q8IRD3
Glutathione peroxidase

2

6

High-throughput

0.571

High

1343016

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

1

High-throughput

0.571

High

1465075

Q9VTY2
Uncharacterized protein, isoform A

2

9

High-throughput

0.571

High

197820

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

2

High-throughput

0.521

High

304666

RS21
Small ribosomal subunit protein eS21

2

1

High-throughput

0.521

High

416664

TRYA
Trypsin alpha

2

2

High-throughput

0.521

High

476987

NDKA
Nucleoside diphosphate kinase

2

4

High-throughput

0.521

High

712381

CALR
Calreticulin

2

12

High-throughput

0.521

High

762587

UCHL
Ubiquitin carboxyl-terminal hydrolase

2

8

High-throughput

0.521

High

1269462

Q7KTW5
Inositol-1-monophosphatase

2

2

High-throughput

0.521

High

1374526

NACA
Nascent polypeptide-associated complex subunit alpha

2

3

High-throughput

0.521

High

1445387

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

1

High-throughput

0.521

High

1464311

Q9V3V2
peptidylprolyl isomerase

2

10

High-throughput

0.521

High

1465030

Q9VEB1
Malate dehydrogenase, mitochondrial

2

4

High-throughput

0.521

High

1465035

Q9VGK3
peptidylprolyl isomerase

2

11

High-throughput

0.521

High

1465068

Q9VRD6
NTF2-related export protein

2

2

High-throughput

0.521

High

1465073

Q9VSL2
Glutathione S transferase O3

2

6

High-throughput

0.521

High

1465076

Q9VU35
10 kDa heat shock protein, mitochondrial

2

4

High-throughput

0.521

High

1465096

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

12

High-throughput

0.521

High

1191678

Q3YMU0
Protein disulfide-isomerase

1

18

High-throughput

0.514

High

1440251

Q9I7K7
Arrestin C-terminal-like domain-containing protein

1

4

High-throughput

0.514

High

1465079

Q9VVL7
Dihydrolipoyl dehydrogenase

1

10

High-throughput

0.514

High

583388

DORS
Embryonic polarity protein dorsal

1

3

High-throughput

0.508

High

1267438

Q7KM03
cyclin-dependent kinase

1

7

High-throughput

0.481

High

53773

A1Z850
Superoxide dismutase [Cu-Zn]

1

7

High-throughput

0.479

High

56514

A1ZAA5
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.479

High

304986

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

1262955

RHINO
Chromo domain-containing protein rhino

1

1

High-throughput

0.479

High

1305151

Q8IQ53
GEO11416p1

1

2

High-throughput

0.479

High

1306686

Q8IRS7
Ciboulot, isoform C

1

2

High-throughput

0.479

High

1465036

Q9VGM2
Fatty acid-binding protein, muscle

1

2

High-throughput

0.479

High

1465097

RAE1
Protein Rae1

1

8

High-throughput

0.479

High

1465060

HPF1
Histone PARylation factor 1-like

1

0

High-throughput

0.458

High

1465098

TREA
Trehalase

1

0

High-throughput

0.458

High

120665

M9PE01
cyclin-dependent kinase

1

7

High-throughput

0.457

High

47785

A0AQH0
Proteasome subunit beta

1

4

High-throughput

0.445

High

121272

ALDR
Aldo-keto reductase 1B

1

9

High-throughput

0.445

High

262675

LOK
Ovarian-specific serine/threonine-protein kinase Lok

1

4

High-throughput

0.445

High

305230

TRMB
tRNA

1

1

High-throughput

0.445

High

305690

IPYR
Inorganic pyrophosphatase

1

3

High-throughput

0.445

High

357329

O97428
Ciboulot, isoform A

1

2

High-throughput

0.445

High

426734

HP1
Heterochromatin protein 1

1

1

High-throughput

0.445

High

458117

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

7

High-throughput

0.445

High

460101

ALF
Fructose-bisphosphate aldolase

1

9

High-throughput

0.445

High

556727

PSA1
Proteasome subunit alpha type-1

1

5

High-throughput

0.445

High

627013

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

648918

ANXB9
Annexin B9

1

5

High-throughput

0.445

High

726395

VATB
V-type proton ATPase subunit B

1

9

High-throughput

0.445

High

821884

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.445

High

822072

PSB1
Proteasome subunit beta type-1

1

8

High-throughput

0.445

High

835168

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.445

High

856069

MOEH
Moesin/ezrin/radixin homolog 1

1

2

High-throughput

0.445

High

874680

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.445

High

929007

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

1

High-throughput

0.445

High

1019891

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.445

High

1026643

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.445

High

1031224

PGK
Phosphoglycerate kinase

1

4

High-throughput

0.445

High

1052253

HMGD
High mobility group protein D

1

3

High-throughput

0.445

High

1173064

ATP5H
ATP synthase subunit d, mitochondrial

1

1

High-throughput

0.445

High

1260838

Q76NR6
Regucalcin

1

2

High-throughput

0.445

High

1262145

Q7JVH6
LD24696p

1

9

High-throughput

0.445

High

1263018

Q7JXC4
CG6459 protein

1

2

High-throughput

0.445

High

1264686

Q7K148
Proteasome subunit beta

1

4

High-throughput

0.445

High

1267920

TERA
Transitional endoplasmic reticulum ATPase TER94

1

10

High-throughput

0.445

High

1268258

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

1

High-throughput

0.445

High

1303921

Q8INK3
Fatty acid-binding protein, muscle

1

2

High-throughput

0.445

High

1305729

Q8IQZ7
FI19014p1

1

6

High-throughput

0.445

High

1321681

Q8MT58
Carnosine dipeptidase 2, isoform A

1

1

High-throughput

0.445

High

1321967

Q8MYY7
RE44624p

1

6

High-throughput

0.445

High

1345248

Q8T0L3
E1 ubiquitin-activating enzyme

1

1

High-throughput

0.445

High

1440032

JUPIT
Microtubule-associated protein Jupiter

1

1

High-throughput

0.445

High

1440127

NASP
Nuclear autoantigenic sperm protein homolog

1

1

High-throughput

0.445

High

1440566

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.445

High

1463652

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

1

High-throughput

0.445

High

1464565

Q9V3V9
Endonuclease G inhibitor, isoform A

1

1

High-throughput

0.445

High

1465014

PSA3
Proteasome subunit alpha type-3

1

7

High-throughput

0.445

High

1465015

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

8

High-throughput

0.445

High

1465016

Q9V9U3
LD45254p

1

2

High-throughput

0.445

High

1465017

Q9VAC1
GM14349p

1

1

High-throughput

0.445

High

1465018

Q9VAC4
GEO09167p1

1

6

High-throughput

0.445

High

1465020

Q9VAN7
Phosphoglycerate mutase

1

5

High-throughput

0.445

High

1465026

Q9VCK6
LD34157p

1

1

High-throughput

0.445

High

1465027

Q9VD02
GH14779p

1

3

High-throughput

0.445

High

1465031

FLNA
Filamin-A

1

9

High-throughput

0.445

High

1465033

Q9VG31
Malic enzyme

1

1

High-throughput

0.445

High

1465037

TCTP
Translationally-controlled tumor protein homolog

1

2

High-throughput

0.445

High

1465038

TEBPH
Cytosolic Prostaglandin E synthase

1

2

High-throughput

0.445

High

1465039

Q9VHN7
transketolase

1

8

High-throughput

0.445

High

1465041

Q9VHX4
LD24679p

1

9

High-throughput

0.445

High

1465043

Q9VIE8
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.445

High

1465045

Q9VKW5
Prolyl endopeptidase

1

5

High-throughput

0.445

High

1465046

EF1D
Probable elongation factor 1-delta

1

1

High-throughput

0.445

High

1465050

Q9VLB7
Rab GDP dissociation inhibitor

1

1

High-throughput

0.445

High

1465051

AK200
A-kinase anchor protein 200

1

4

High-throughput

0.445

High

1465058

PSB4
Proteasome subunit beta type-4

1

9

High-throughput

0.445

High

1465065

BACC
Bacchus

1

1

High-throughput

0.445

High

1465066

Q9VQL1
serine--tRNA ligase

1

3

High-throughput

0.445

High

1465069

Q9VRL1
GEO06356p1

1

2

High-throughput

0.445

High

1465072

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

3

High-throughput

0.445

High

1465074

Q9VTX2
RE32936p

1

1

High-throughput

0.445

High

1465077

Q9VUC1
Hsc70Cb, isoform A

1

7

High-throughput

0.445

High

1465080

Q9VW59
Rho GDP-dissociation inhibitor 3

1

1

High-throughput

0.445

High

1465082

RS10B
Small ribosomal subunit protein eS10B

1

3

High-throughput

0.445

High

1465086

Q9VXQ3
Diphosphomevalonate decarboxylase

1

1

High-throughput

0.445

High

1465088

CLIC
Chloride intracellular channel Clic

1

6

High-throughput

0.445

High

1465094

SND1
Staphylococcal nuclease domain-containing protein 1

1

5

High-throughput

0.445

High

1465100

Q9W3Y3
Calcyclin-binding protein

1

1

High-throughput

0.445

High

1465102

WUHO
tRNA

1

10

High-throughput

0.445

High

1465104

Q9W457
Serine hydroxymethyltransferase

1

2

High-throughput

0.445

High

1465106

PSB3
Proteasome subunit beta type-3

1

7

High-throughput

0.445

High

1465109

PSA6
Proteasome subunit alpha type-6

1

8

High-throughput

0.445

High

1465111

Q9Y112
BcDNA.GH10614

1

9

High-throughput

0.445

High

120791

M9PE30
Transgelin

1

6

High-throughput

0.437

High

654316

DDX6
ATP-dependent RNA helicase me31b

1

2

High-throughput

0.437

High

1465024

Q9VC92
Acyl-CoA synthetase short-chain family member 3, mitochondrial

1

2

High-throughput

0.437

High

1465029

Q9VD30
GH05294p

1

1

High-throughput

0.437

High

1465052

WDR82
WD repeat-containing protein 82

1

12

High-throughput

0.437

High

1465090

Q9VYR1
Regucalcin

1

2

High-throughput

0.437

High

1465095

Q9W0U6
Sulfatase-modifying factor enzyme-like domain-containing protein

1

1

High-throughput

0.437

High

1465103

NEP
Neprilysin-1

1

3

High-throughput

0.437

High

145977

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

1464505

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.426

High

1465025

ORN
Probable oligoribonuclease

1

0

High-throughput

0.426

High

1465040

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

1465057

GUAD
Guanine deaminase

1

0

High-throughput

0.426

High

1465085

SUN
Protein stunted

1

0

High-throughput

0.426

High

57601

A1ZB71
Glutathione S transferase E6

1

10

High-throughput

0.407

High

57827

A1ZB77
Uncharacterized protein, isoform J

1

1

High-throughput

0.407

High

86534

B9EQV3
Endoplasmic reticulum transmembrane protein

1

4

High-throughput

0.407

High

197350

O18335
Rab11

1

5

High-throughput

0.407

High

234595

VINC
Vinculin

1

2

High-throughput

0.407

High

357552

INO1
Inositol-3-phosphate synthase

1

1

High-throughput

0.407

High

682785

PROF
Profilin

1

3

High-throughput

0.407

High

930177

VATE
V-type proton ATPase subunit E

1

1

High-throughput

0.407

High

1052438

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.407

High

1069636

Q0E8X8
ATP synthase F1 subunit epsilon

1

2

High-throughput

0.407

High

1070784

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

2

High-throughput

0.407

High

1176297

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

10

High-throughput

0.407

High

1265265

Q7K2K2
FI04612p

1

1

High-throughput

0.407

High

1322041

Q8MZ13
RE19958p

1

2

High-throughput

0.407

High

1343315

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.407

High

1374669

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.407

High

1377645

FAXC
Failed axon connections

1

2

High-throughput

0.407

High

1427844

IF5A
Eukaryotic translation initiation factor 5A

1

1

High-throughput

0.407

High

1458046

GCSH
Glycine cleavage system H protein, mitochondrial

1

1

High-throughput

0.407

High

1465019

Q9VAG3
trypsin

1

2

High-throughput

0.407

High

1465021

Q9VAY2
Heat shock protein 83

1

9

High-throughput

0.407

High

1465022

Q9VBR6
RE74917p

1

2

High-throughput

0.407

High

1465028

Q9VD29
small monomeric GTPase

1

8

High-throughput

0.407

High

1465042

Q9VIC3
carboxylesterase

1

2

High-throughput

0.407

High

1465044

Q9VKB0
threonine--tRNA ligase

1

3

High-throughput

0.407

High

1465047

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

5

High-throughput

0.407

High

1465048

Q9VL70
HL08109p

1

2

High-throughput

0.407

High

1465049

FKB59
FK506-binding protein 59

1

7

High-throughput

0.407

High

1465053

Q9VLS7
LD21067p

1

2

High-throughput

0.407

High

1465056

Q9VMU6
LD31822p

1

3

High-throughput

0.407

High

1465059

Q9VNB2
RE42193p

1

1

High-throughput

0.407

High

1465062

Q9VP52
GH24315p

1

1

High-throughput

0.407

High

1465063

Q9VPN5
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.407

High

1465064

Q9VPX6
Adenylyl cyclase-associated protein

1

1

High-throughput

0.407

High

1465070

Q9VRP2
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

1465078

Y9705
Cold shock domain-containing protein CG9705

1

1

High-throughput

0.407

High

1465081

Q9VW70
FI21813p1

1

2

High-throughput

0.407

High

1465084

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.407

High

1465091

Q9VZI1
Transgelin

1

6

High-throughput

0.407

High

1465099

Q9W3X6
fumarate hydratase

1

3

High-throughput

0.407

High

1465101

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.407

High

1465105

Q9W478
RE43153p

1

2

High-throughput

0.407

High

1465107

Q9XYZ9
Glutathione S transferase E12, isoform A

1

7

High-throughput

0.407

High

1465108

Q9XZ57
Eb1, isoform E

1

3

High-throughput

0.407

High

1465110

PURA
Adenylosuccinate synthetase

1

1

High-throughput

0.407

High

1465032

Q9VFP6
Inositol polyphosphate 1-phosphatase

2

0

High-throughput

0.310

High

1465055

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.310

High

1465067

Q9VRD4
Uncharacterized protein, isoform A

2

0

High-throughput

0.298

High

121034

M9PEN9
Uncharacterized protein, isoform B

1

0

High-throughput

0.249

Low

1264996

ARC1
Activity-regulated cytoskeleton associated protein 1

1

0

High-throughput

0.249

Low

1440485

Q9I7N2
Nucleoporin NUP42

1

0

High-throughput

0.249

Low

1465083

NARYA
RING finger protein narya

1

0

High-throughput

0.249

Low

53853

A1Z864
FI01421p

1

0

High-throughput

0.232

Low

356558

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.232

Low

1014716

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

1266802

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

1286127

QPCT2
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.232

Low

1445625

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1465023

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1465034

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1465054

Q9VLV9
Proctolin

1

0

High-throughput

0.232

Low

1465071

Q9VS98
LD12639p

1

0

High-throughput

0.232

Low

1465087

ASGL1
Probable isoaspartyl peptidase/L-asparaginase CG7860

1

0

High-throughput

0.232

Low

1465089

Q9VYB9
LP02557p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025