HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: KS6A2 (Q15349)
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
Gene: RPS6KA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 733
+	Hs
		909590 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Dm
		955037 1433E_DROME (2-247): 2.8e-144: 405: 58.07		Q9VR61_DROME (20-727): 0: 716: 53.67
+	Hs
		646741 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		646913 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		270395 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		KS6A5_HUMAN (38-727): 0: 712: 41.00
+	Hs
		683216 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		683368 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		272848 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6A4_HUMAN (45-732): 0: 655: 40.80
+	Hs
		272852 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		KS6A4_HUMAN (45-732): 0: 655: 40.80
+	Hs
		681682 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		681770 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		568616 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		681776 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		568620 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	At
		788319 14331_ARATH (3-241): 4.5e-144: 405: 56.85		KPK1_ARATH (413-705): 9.84e-100: 316: 28.11
+	Hs
		647354 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6B2_HUMAN (415-726): 8.17e-118: 364: 27.88
+	Hs
		610682 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KAPCB_HUMAN (402-707): 4.06e-118: 360: 29.78
+	Mm
		926837 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		KS6A5_MOUSE (133-315): 4.5e-67: 239: 30.96
+	Hs
		116995 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SGK1_HUMAN (421-669): 7.7e-28: 119: 32.69
+	Hs
		116972 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		SGK1_HUMAN (421-669): 7.7e-28: 119: 32.69