HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1192
+	Hs
		909674 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		WWC2_HUMAN (1-1192): 0: 1008: 100.00
+	Hs
		909790 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		684280 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MAGI1_HUMAN (1-300): 2.32e-62: 236: 18.94
+	Hs
		684266 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ITCH_HUMAN (7-143): 1.17e-33: 142: 24.66
+	Hs
		125183 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		684324 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Hs
		125318 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		910022 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Hs
		683894 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Mm
		808343 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NEDD4_MOUSE (54-164): 5.95e-20: 98.5: 19.30
+	Hs
		683895 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		684276 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Mm
		93259 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		E9PXB7_MOUSE (1-141): 7.04e-09: 62.3: 17.01
+	Mm
		910341 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		RIMS2_MOUSE (556-832): 3.94e-13: 76.6: 13.78
+	Hs
		808077 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Rn
		910358 1433E_RAT (2-246): 4.41e-146: 410: 60.41		NEDD4_RAT (1-241): 4.08e-10: 66.5: 15.32
+	Hs
		808460 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		909930 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Mm
		910302 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NED4L_MOUSE (1-141): 7.95e-09: 62.3: 17.01
+	Mm
		93264 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		E9PXB7_MOUSE (1-141): 7.04e-09: 62.3: 17.01