HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: ARG28 (Q8N1W1)
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Gene: ARHGEF28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1705
+	Hs
		909803 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ARG28_HUMAN (1-1705): 0: 1234: 100.00
+	Mm
		910228 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		ARG28_MOUSE (1-1705): 0: 1165: 80.09
+	Mm
		926776 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		ARG28_MOUSE (1-1705): 0: 1165: 80.09
+	Hs
		684001 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AKP13_HUMAN (1-814): 3.86e-122: 429: 17.82
+	Hs
		909491 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AKP13_HUMAN (1-814): 3.86e-122: 429: 17.82
+	Hs
		684253 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ARHG2_HUMAN (615-1525): 1.22e-103: 358: 35.81
+	Hs
		909883 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ARHG2_HUMAN (615-1525): 1.22e-103: 358: 35.81
+	Hs
		684147 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FGD6_HUMAN (289-1349): 1.08e-90: 327: 13.66
+	Mm
		926817 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		ARHGI_MOUSE (328-1659): 4.59e-103: 364: 30.75
+	Mm
		926797 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		ARHG2_MOUSE (615-1525): 6.37e-103: 356: 34.81
+	Hs
		909717 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FGD6_HUMAN (289-1349): 1.08e-90: 327: 13.66
+	Hs
		684273 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ARHGH_HUMAN (391-1384): 1.6e-72: 271: 15.35
+	Hs
		909933 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ALS2_HUMAN (335-1261): 1.6e-79: 293: 13.19
+	Hs
		684271 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SPT13_HUMAN (634-1221): 9.84e-74: 262: 13.55
+	Hs
		910068 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ARHG4_HUMAN (815-1275): 1.7e-76: 271: 15.32
+	Hs
		909921 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SPT13_HUMAN (634-1221): 9.84e-74: 262: 13.55
+	Hs
		506563 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		BCR_HUMAN (401-1283): 7.4e-70: 260: 13.08
+	Sp
		788722 RAD24_SCHPO (2-248): 5.1e-136: 385: 54.66		RGF1_SCHPO (411-1199): 8.04e-77: 283: 13.15
+	Mm
		926773 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		RGRF2_MOUSE (612-1491): 2.19e-70: 262: 12.40
+	Hs
		506568 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		BCR_HUMAN (401-1283): 7.4e-70: 260: 13.08