HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: DTL (Q9NZJ0)
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
Gene: DTL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25154416, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 730
+	Hs
		910100 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		927593 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		647330 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		683763 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		905191 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		982557 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		DTL_HUMAN (1-730): 8.94e-163: 489: 100.00
+	Hs
		684254 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		909885 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		927381 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		903106 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		792954 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Hs
		927391 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		792963 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Hs
		647171 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		683605 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		904953 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		683188 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Hs
		792950 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23
+	Mm
		935526 1433F_MOUSE (2-242): 1.72e-96: 284: 64.20		SNR40_MOUSE (258-581): 2.48e-38: 147: 14.20
+	Hs
		792974 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		LIS1_HUMAN (260-499): 2.94e-36: 143: 15.23