HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.666

Property	Details
Experiments	31980649, 36931259, unassigned2173, 19172738
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 676
+	Hs
		910172 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		910246 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		926790 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		926898 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		684018 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		909527 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		684083 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		DOC11_HUMAN (2-457): 1.02e-111: 372: 16.08
+	Hs
		909638 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DOC11_HUMAN (2-457): 1.02e-111: 372: 16.08
+	Hs
		684119 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		909680 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		910041 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PKHA2_HUMAN (2-229): 1.67e-55: 197: 21.55
+	Hs
		909993 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DOCK9_HUMAN (2-485): 1.15e-51: 196: 12.16
+	Hs
		684334 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		684333 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		910043 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		684165 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		684169 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PHLB1_HUMAN (8-113): 8.34e-17: 87: 26.27
+	Hs
		910040 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		909748 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		909755 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PHLB1_HUMAN (8-113): 8.34e-17: 87: 26.27