HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1338
+	Hs
		910201 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Hs
		927703 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Hs
		683873 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		151721 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		724526 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724581 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151760 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		724528 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Dm
		955052 1433E_DROME (2-247): 2.8e-144: 405: 58.07		IRS1_DROME (27-983): 1.28e-75: 274: 17.98
+	Hs
		151765 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		297821 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		297824 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		684368 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02
+	Hs
		909737 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		927045 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		MDC1_HUMAN (414-1332): 5.89e-20: 99.2: 9.03
+	Hs
		909712 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75
+	Hs
		910111 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02
+	Hs
		927220 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		927196 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75
+	Hs
		927605 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02