Protein: EIF3K
Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28)

Gene: EIF3K
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q9UBQ5

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458622

EIF3L
Eukaryotic translation initiation factor 3 subunit L

12

2

Small-scale

0.984

High

949456

EIF3E
Eukaryotic translation initiation factor 3 subunit E

7

1

Small-scale

0.964

High

1271683

EIF3M
Eukaryotic translation initiation factor 3 subunit M

7

1

Small-scale

0.964

High

131525

EIF3F
Eukaryotic translation initiation factor 3 subunit F

6

4

Small-scale

0.944

High

1121904

EIF3A
Eukaryotic translation initiation factor 3 subunit A

5

2

Small-scale

0.919

High

1405779

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

1

Small-scale

0.893

High

188052

EIF3H
Eukaryotic translation initiation factor 3 subunit H

7

5

Small-scale

0.747

High

939451

EIF3B
Eukaryotic translation initiation factor 3 subunit B

4

1

Small-scale

0.697

High

295249

EIF3G
Eukaryotic translation initiation factor 3 subunit G

4

1

Small-scale

0.696

High

1102920

EIF3I
Eukaryotic translation initiation factor 3 subunit I

5

0

High-throughput

0.688

High

187813

EIF3D
Eukaryotic translation initiation factor 3 subunit D

4

0

Small-scale

0.660

High

128331

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.656

High

1124316

IF4A2
Eukaryotic initiation factor 4A-II

3

1

High-throughput

0.650

High

295367

EIF3J
Eukaryotic translation initiation factor 3 subunit J

3

0

Small-scale

0.636

High

343094

HERC2
E3 ubiquitin-protein ligase HERC2

3

2

Small-scale

0.633

High

1370431

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.618

High

718914

CCND3
G1/S-specific cyclin-D3

2

0

Small-scale

0.614

High

998086

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.611

High

951494

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.585

High

1047129

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

2

Small-scale

0.584

High

564496

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

397132

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

831579

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

714486

PML
Protein PML

1

0

Small-scale

0.549

High

631532

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

227184

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

1

High-throughput

0.536

High

775355

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

832139

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.536

High

1127219

RBM39
RNA-binding protein 39

1

1

High-throughput

0.536

High

1198216

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.536

High

1413404

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

1447834

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.536

High

1458620

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.536

High

1458624

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

141690

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.513

High

271583

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

303650

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

407137

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

431267

LA
Lupus La protein

1

0

High-throughput

0.513

High

445608

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

447536

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

479484

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

484672

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

542263

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

581597

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

687315

HMGB2
High mobility group protein B2

1

0

High-throughput

0.513

High

765965

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.513

High

785505

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

859489

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

867483

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

872042

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.513

High

884256

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

886602

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

897095

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

933363

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

970152

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

985934

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

993010

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.513

High

1126565

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1136079

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1229259

RHG17
Rho GTPase-activating protein 17

1

0

High-throughput

0.513

High

1313600

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1337711

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1339748

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

1360518

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1369506

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1405149

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

1417982

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.513

High

1431719

TARA
TRIO and F-actin-binding protein

1

0

High-throughput

0.513

High

1453824

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

1458617

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1458623

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

1458628

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

254652

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

167411

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

132359

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

216133

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.479

High

243187

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

316111

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

316640

ST17B
Serine/threonine-protein kinase 17B

1

2

High-throughput

0.479

High

427949

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.479

High

625683

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.479

High

684422

DDX6
Probable ATP-dependent RNA helicase DDX6

1

1

High-throughput

0.479

High

1101075

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

1109573

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1109590

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.479

High

1280567

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1337848

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1367492

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1458614

ST17A
Serine/threonine-protein kinase 17A

1

2

High-throughput

0.479

High

1458618

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1458619

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1458629

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

170403

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

320114

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

325150

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

339355

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.458

High

363968

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

442509

GELS
Gelsolin

1

0

High-throughput

0.458

High

565487

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

589936

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

607184

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

660744

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

674360

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.458

High

675192

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

696758

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

822895

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

935233

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

941293

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

947301

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

948485

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.458

High

948956

CD81
CD81 antigen

1

0

High-throughput

0.458

High

957541

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

971231

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1092264

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1098382

ERCC8
DNA excision repair protein ERCC-8

1

0

Small-scale

0.458

High

1114539

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1138714

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1155863

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1161730

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1164095

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.458

High

1229738

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1241828

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1288599

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1358132

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1364649

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1380602

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

1385898

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1403604

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1420977

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1446990

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1448114

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1458615

TRM7
tRNA

1

0

High-throughput

0.458

High

1458616

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1458621

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

1458626

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

1458627

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

75497

B3KS98
Eukaryotic translation initiation factor 3 subunit H

1

5

High-throughput

0.445

High

171603

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.445

High

516601

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

1240978

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

1243674

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.445

High

883352

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.438

High

1156885

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

401642

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

530506

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

567508

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

1057014

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

1203279

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1209757

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

160018

IDLC
Axonemal dynein light intermediate polypeptide 1

2

0

High-throughput

0.324

High

389551

FINC
Fibronectin

1

0

High-throughput

0.279

Low

1142203

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1446147

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.279

Low

1458625

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.279

Low

522305

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

762501

PROF2
Profilin-2

1

0

High-throughput

0.249

Low

769412

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879573

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1255933

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1286754

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

1348001

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

1434131

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

87551

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

619947

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

1034536

TAGL
Transgelin

1

0

High-throughput

0.232

Low

1214213

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025