HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0045296 - cadherin binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 639
+	Mm
		926851 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		ARHG6_MOUSE (57-634): 1.66e-67: 237: 14.55
+	Hs
		253322 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Mm
		910322 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		SRGP2_MOUSE (2-443): 2.8e-44: 172: 11.52
+	Hs
		253335 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		275184 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		909743 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SRGP1_HUMAN (2-455): 4.74e-38: 153: 13.51
+	Hs
		909427 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		253338 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		298953 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		684142 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		684082 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		298967 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		299007 V9HW98_HUMAN (2-246): 4.41e-146: 410: 60.41		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		909849 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		909706 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		909551 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Hs
		298968 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		909634 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Mm
		910242 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		SRBS2_MOUSE (258-329): 5.28e-09: 61.5: 20.83
+	Mm
		926883 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17