HitPredict

Interactor 1: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	11453982, 9232445, 10382761
Identification Methods	unspecified method, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032760 - positive regulation of tumor necrosis factor production
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 310 Hs			1 593
+	Hs
		519378 FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665804 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		986005 FCGRB_HUMAN (28-258): 2.8e-49: 167: 37.07		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986016 FCRL3_HUMAN (1-305): 2.08e-25: 108: 17.39		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		665992 FCRL5_MOUSE (5-253): 1.79e-34: 133: 19.33		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		532367 CEAM1_HUMAN (19-298): 1.53e-16: 81.8: 13.15		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		682308 CEAM1_MOUSE (46-295): 1e-10: 64: 17.46		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		665941 FCRL3_HUMAN (1-305): 2.08e-25: 108: 17.39		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665976 CD22_MOUSE (3-308): 2.01e-25: 108: 14.96		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		532361 CEAM1_HUMAN (19-298): 1.53e-16: 81.8: 13.15		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		590601 CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		616914 CNTN1_HUMAN (1-310): 6.29e-30: 121: 12.13		PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91
+	Dm
		1308480 Q9BN17_DROME (97-242): 5.8e-14: 74.4: 13.61		Q9W4F5_DROME (191-560): 1.41e-112: 371: 29.38
+	Gg
		47583 CNTN1_CHICK (113-300): 1.02e-14: 76.7: 11.33		A0A8V0YWD3_CHICK (33-522): 1.95e-110: 353: 24.25
+	Hs
		1069952 PXDN_HUMAN (122-305): 1.66e-29: 120: 11.40		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94
+	Hs
		617163 CNTN1_HUMAN (1-310): 6.29e-30: 121: 12.13		PTPRZ_HUMAN (33-537): 1.15e-65: 235: 16.73
+	Hs
		441175 CD22_HUMAN (92-310): 1.59e-09: 60.9: 13.33		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Dr
		60061 A4JYP8_DANRE (30-201): 1.38e-17: 85.2: 19.50		B8A5J4_DANRE (40-528): 1.48e-61: 223: 17.19
+	Dr
		47534 A4JYP8_DANRE (30-201): 1.38e-17: 85.2: 19.50		A0A8M1RL98_DANRE (33-528): 1.18e-59: 217: 18.62